Evidence map›Paper›PMID 27581799›Full record

ArticleObesity surgery2017

A Simple Food-Diverting Operation for Type 2 Diabetes Treatment. Preliminary Results in Humans with BMI 28-32 kg/m

John Melissas, Halit ErenTaskin, Drakos Peirasmakis, Efstathios Dimitriadis, Marios Papadakis, Seniyye Ulgen Zengin, Volkan Yumuk, Mustafa Taskin

Abstract readCase Reports
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In one paragraph

Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  7. A rodent model of partial intestinal diversion: a novel metabolic operation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

John MelissasBariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, Medical School, University of Crete, 164 Erythreas str, Heraklion, 71409, Greece. melissas@med.uoc.gr.
Halit ErenTaskinDepartment of General Surgery, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Drakos PeirasmakisBariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, Medical School, University of Crete, 164 Erythreas str, Heraklion, 71409, Greece.
Efstathios DimitriadisBariatric Unit, Department of Surgical Oncology, Heraklion University Hospital, Medical School, University of Crete, 164 Erythreas str, Heraklion, 71409, Greece.
Marios PapadakisUniversity Hospital Witten/Herdecke, Wuppertal, Germany.
Seniyye Ulgen ZenginDepartment of Anesthesiology and Reanimation, Bezmi Alem Vakif University, Istanbul, Turkey.
Volkan YumukDepartment of Endocrinology and Metabolism, Cerrahpasa, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Mustafa TaskinDepartment of General Surgery, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Istanbul University · TRUniversity Hospital of Heraklion · GRBezmiâlem Vakıf Üniversitesi · TRUniversity of Crete · GRWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe feasibility of a simple side-to-side jejunoileal anastomosis (SJA) in non-morbidly obese individuals to control type 2 diabetes mellitus (T2DM) was studied in six diabetic patients with BMI 28-32. This novel procedure was performed in two Academic Centers and preliminary data is presented.

methodsSJA bypassing a significant part of the small bowel and diverting food and biliopancretic secretions to the distal ileum was performed laparoscopically in six diabetic patients with BMI 28-32 kg/m

resultsThree of the patients (two female, one male) experienced complete remission of diabetes from the immediate postoperative period and up to 3 years after the procedure. Two other patients remained medication-free after the operation experiencing partial diabetes remission, and the third patient significantly reduced his daily insulin requirements immediately after surgery. There were no early or late postoperative complications.

conclusionsA simple SJA, diverting the food and biliopancreatic secretion to the distal small bowel, was able to control T2DM in all patients offering total or partial remission of the disease soon after the procedure. Those preliminary data and the simplicity of the operation are encouraging and promising. However, further studies are in progress in both Institutions to reveal the possible mechanism of diabetes control and investigate the effect of this operation on larger number of patients, with longer follow-up period.

Indexed as

AdultAnastomosis, SurgicalBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2Feasibility StudiesFemaleGastric BypassHumansIleumJejunumLaparoscopyMaleMiddle AgedObesityRemission InductionBlood GlucoseDiabetes type 2Jejunoileal anastomosisMetabolic surgery

Identifiers

PMID27581799
OpenAlexW2517993204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.