Evidence map›Paper›PMID 27581702›Full record

ArticleNeurogastroenterology and motility2017

Fecal incontinence in irritable bowel syndrome: Prevalence and associated factors in Swedish and American patients.

M Simrén, O S Palsson, S Heymen, A Bajor, H Törnblom, W E Whitehead

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Neurogastroenterology and motility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03489265 (Treatment of Diarrhea-Associated Fecal Incontinence With Eluxadoline), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03489265 phase2withdrawnnot on this mapstarted 2019, after this paper: background citation

Treatment of Diarrhea-Associated Fecal Incontinence With Eluxadoline

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2020Enrolled0ConditionsFecal Incontinence, Accidental Bowel Leakage, Anal Incontinence, DiarrheaArmsEluxadoline 100 mg, Placebo
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Stress reduction and psychological therapy for IBS: a scoping review.Frontiers in gastroenterology (Lausanne, Switzerland) · 2024
    Review
  4. Article
  5. Characteristics of Fecal Incontinence in Male Patients in Japan.Journal of the anus, rectum and colon · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Risk Factors for Fecal Urgency Among Individuals With and Without Diarrhea, Based on Data From the National Health and Nutrition Examination Survey.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

M SimrénDepartment of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
O S PalssonCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S HeymenCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
A BajorDepartment of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
H TörnblomDepartment of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
W E WhiteheadCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USUniversity of Gothenburg · SE

Funding

PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROMER01DK031369 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITEHEAD, WILLIAM E · 1986 to 2012
$6.3M
NIDDK NIH HHS R01 DK031369
6 · The paper itself

Abstract

backgroundFecal incontinence (FI) is a prevalent but poorly recognized problem in the general population with profound negative effects on daily life. The prevalence of FI in irritable bowel syndrome (IBS) and its association with clinical, demographic, and pathophysiological factors remain largely unknown.

methodsOne US (n=304) and one Swedish (n=168) patient cohort fulfilling Rome III criteria for IBS completed Rome III diagnostic questions on FI and IBS symptoms, and questionnaires on IBS symptom severity, quality of life, anxiety and depression, and work productivity impairment. The patients also underwent assessments of colorectal sensitivity and motility. KEY

resultsFecal incontinence ≥ one day per month was reported by 19.7% (USA) and 13.7% (Sweden) of IBS patients. These proportions rose to 43.4% and 29.8% if patients with less frequent FI were included. Fecal incontinence prevalence was higher in older age groups, with a clear increase above age 40. Irritable bowel syndrome patients with FI reported greater overall IBS symptom severity, more frequent and loose stools, and greater urgency. Negative effects of FI on quality of life, psychological distress, and work productivity were demonstrated. No associations were found between colorectal physiology and FI. CONCLUSIONS & INFERENCES: Fecal incontinence is common in IBS patients, and similar to previous general population reports, the major risk factors for FI in IBS are older age, rectal urgency, and loose, frequent stools. When IBS patients have comorbid FI, the impact on quality of life, psychological symptoms, and work impairment appears greater.

Indexed as

AdolescentAdultAgedCohort StudiesFecal IncontinenceFemaleHumansIrritable Bowel SyndromeMaleMiddle AgedPrevalenceProspective StudiesQuality of LifeRisk FactorsSurveys and QuestionnairesSwedenfecal incontinencefunctional GI disordersirritable bowel syndrome

Identifiers

PMID27581702
PMCPMC5276715
OpenAlexW2516216178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.