ArticleThe American journal of clinical nutrition2016
Maternal protein intake during pregnancy and linear growth in the offspring.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02820402 (Project Viva), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project Viva: a Longitudinal Study of Health for the Next Generation
Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Associations Between Paternal Pre-Conceptional Body Mass Index and Lifestyle Factors and Offspring Weight Development.Pediatric obesity · 2026Trial
- Food desert residence and prenatal diet quality.Pregnancy (Hoboken, N.J.) · 2026Article
- Addressing Childhood Malnutrition in Europe: Policy Approaches to Promote Healthy Eating in Young Children.Children (Basel, Switzerland) · 2026Review
- Maternal Lifestyle During Pregnancy and Its Influence on Offspring's Telomere Length.Life (Basel, Switzerland) · 2025Review
- Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length.Nutrients · 2023Review
- Associations between High Protein Intake, Linear Growth, and Stunting in Children and Adolescents: A Cross-Sectional Study.Nutrients · 2023Article
- Maternal Dietary Protein Patterns and Neonatal Anthropometrics: A Prospective Study with Insights from NMR Metabolomics in Amniotic Fluid.Metabolites · 2023Article
- No strong evidence of the protein leverage hypothesis in pregnant women with obesity and their infants.Obesity (Silver Spring, Md.) · 2023Article
- Article
- Maternal protein intake in early pregnancy and child development at age 3 years.Pediatric research · 2023Article
- Is It Time to Reconsider the U.S. Recommendations for Dietary Protein and Amino Acid Intake?Nutrients · 2023Review
- Dietary protein intake during pregnancy and birth weight among Chinese pregnant women with low intake of protein.Nutrition & metabolism · 2022Article
- The Clinical Characteristics and Outcomes of Hemorrhagic Fever With Renal Syndrome in Pregnancy.Frontiers in medicine · 2022Article
- Maternal Dietary Intake of Total Fat, Saturated Fat, and Added Sugar Is Associated with Infant Adiposity and Weight Status at 6 mo of Age.The Journal of nutrition · 2021Observational
- Article
- Macronutrient Intake in Pregnancy and Child Cognitive and Behavioural Outcomes.Children (Basel, Switzerland) · 2021Article
- Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size.Endocrine connections · 2021Article
- Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts.Cellular and molecular life sciences : CMLS · 2021Article
- Association between the maternal protein nutrition status during pregnancy and the risk of preterm birth.Maternal & child nutrition · 2021Article
- Prevalence of Hypoproteinemia and Hypoalbuminemia in Pregnant Women from Three Different Socioeconomic Populations.International journal of environmental research and public health · 2020Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObservational and experimental evidence demonstrates that protein intake in infancy programs linear growth. To our knowledge, few studies have examined prenatal maternal protein intake.
objectiveOur objective was to examine associations of maternal protein intake during pregnancy with offspring linear growth.
designWe analyzed data from 1961 mother-child pairs in Project Viva. We assessed first- and second-trimester diet with the use of food-frequency questionnaires and analyzed protein intake as grams per kilogram prepregnancy weight per day. We used research measures of offspring length at birth and in infancy (∼6 mo), early childhood (∼3 y), and midchildhood (∼7 y), as well as clinical growth measures obtained from after birth through midchildhood. We calculated sex-specific birth length z scores for gestational age with the use of international reference data. We used mixed models with repeated length measures to predict individual length gain velocities for birth to <6 mo and 6 mo to 7 y of age, then used these velocities as outcomes in adjusted linear regression models with maternal protein intake as the main predictor.
resultsMean (range) second-trimester protein intake was 1.4 g · kg
conclusionsIn a population with relatively high protein intake during pregnancy, higher protein intake was associated with shorter offspring birth length and slower linear growth into midchildhood. Results suggest that higher protein intake during pregnancy does not increase fetal and child growth and may even reduce early length growth. Project Viva was registered at clinicaltrials.gov as NCT02820402.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.