ReviewThe international journal of cardiovascular imaging2017
A novel approach to diagnosing coronary artery disease: acoustic detection of coronary turbulence.
Review in The international journal of cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial.European heart journal · 2025Trial
- Artificial Intelligence-Assisted Auscultation of Heart Murmurs: Validation by Virtual Clinical Trial.Pediatric cardiology · 2019Trial
- Pre-test probability estimation of coronary artery disease can be improved by adding an acoustic-based risk score.International journal of cardiology. Heart & vasculature · 2025Article
- Sacrificial-Rotating Rod-Based 3D Bioprinting Technique for the Development of an In Vitro Cardiovascular Model.Journal of functional biomaterials · 2023Article
- The Feasibility of Ultra-Sensitive Phonocardiography in Acute Chest Pain Patients of a Tertiary Care Emergency Department (ScorED Feasibility Study).Journal of personalized medicine · 2022Article
- Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population.Heart and vessels · 2021Article
- Advanced heart sound analysis as a new prognostic marker in stable coronary artery disease.European heart journal. Digital health · 2021Article
- Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis.Bioengineering (Basel, Switzerland) · 2021Article
- Effect of stenosis shape on the sound emitted from a constricted blood vessel.Medical & biological engineering & computing · 2020Article
- Coronary artery disease risk reclassification by a new acoustic-based score.The international journal of cardiovascular imaging · 2019Article
- Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration.Medical & biological engineering & computing · 2019Article
- Identifying Patients With Coronary Artery Disease Using Rest and Exercise Seismocardiography.Frontiers in physiology · 2019Article
- Reintroducing Heart Sounds for Early Detection of Acute Myocardial Ischemia in a Porcine Model - Correlation of Acoustic Cardiography With Gold Standard of Pressure-Volume Analysis.Frontiers in physiology · 2019Article
- Diagnostic performance of an acoustic-based system for coronary artery disease risk stratification.Heart (British Cardiac Society) · 2018Article
- Digital stethoscope: technology update.Medical devices (Auckland, N.Z.) · 2018Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerotic disease within coronary arteries causes disruption of normal, laminar flow and generates flow turbulence. The characteristic acoustic waves generated by coronary turbulence serve as a novel diagnostic target. The frequency range and timing of microbruits associated with obstructive coronary artery disease (CAD) have been characterized. Technological advancements in sensor, data filtering and analytic capabilities may allow use of intracoronary turbulence for diagnostic and risk stratification purposes. Acoustic detection (AD) systems are based on the premise that the faint auditory signature of obstructive CAD can be isolated and analyzed to provide a new approach to noninvasive testing. The cardiac sonospectrographic analyzer, CADence, and CADScore systems are early-stage, investigational and commercialized examples of AD systems, with the latter two currently undergoing clinical testing with validation of accuracy using computed tomography and invasive angiography. Noninvasive imaging accounts for a large percentage of healthcare expenditures for cardiovascular disease in the developed world, and the growing burden of CAD will disproportionately affect areas in the developing world. AD is a portable, radiation-free, cost-effective method with the potential to provide accurate diagnosis or exclusion of significant CAD. AD represents a model for digital, miniaturized, and internet-connected diagnostic technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.