ArticleClinical endocrinology2017
Investigation of brain GABA+ in primary hypothyroidism using edited proton MR spectroscopy.
Article in Clinical endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The Cross-sectional and Longitudinal Association Between Thyroid Function and Depression: A Population-Based Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Relationships between GABA, glutamate, and GABA/glutamate and social and olfactory processing in children with autism spectrum disorder.Psychiatry research. Neuroimaging · 2023Article
- Deficiency of Thyroid Hormone Reduces Voltage-Gated NaInternational journal of molecular sciences · 2022Article
- MEGA-PRESS of GABA+: Influences of acquisition parameters.NMR in biomedicine · 2021Article
- Brain GABA+ changes in primary hypothyroidism patients before and after levothyroxine treatment: A longitudinal magnetic resonance spectroscopy study.NeuroImage. Clinical · 2020Article
- Feasibility of Measuring GABA Levels in the Upper Brainstem in Healthy Volunteers Using Edited MRS.Frontiers in psychiatry · 2020Article
- Inhibitory motor dysfunction in parkinson's disease subtypes.Journal of magnetic resonance imaging : JMRI · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveEvidence indicates that thyroid hormones have effects on the inhibitory GABAergic system. The aim of this study was to investigate whether brain GABA levels are altered in patients with hypothyroidism compared with healthy controls. DESIGN/
methodsFifteen patients with primary hypothyroidism and 15 matched healthy controls underwent single-voxel MEGA-PRESS magnetic resonance spectroscopy at 3T, to quantify GABA levels in the median prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). All participants underwent thyroid function test. Neuropsychological performances were evaluated by administration of the Montreal Cognitive Assessment (MoCA) and the 21-item Beck Depression Inventory-II (BDI-II).
resultsThe patients with hypothyroidism had significantly lower GABA+ levels in the mPFC compared with healthy controls (P = 0·016), whereas no significant difference (P = 0·214) was observed in the PCC. Exploratory analyses revealed that mPFC GABA+ levels were negatively correlated with the BDI-II scores in patient group (r = -0·60, P = 0·018). No correlations were found between GABA+ levels and TSH or fT3 or fT4 levels in either region (all P > 0·05).
conclusionThis study suggests that alteration of GABAergic neurotransmission may play an important role in the pathophysiology of primary hypothyroidism, providing intriguing neurochemical clues to understand thyroid-brain interactions.
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