Evidence map›Paper›PMID 27581303›Full record

ArticleMetabolic brain disease2017

Hair toxic and essential trace elements in children with autism spectrum disorder.

Anatoly V Skalny, Natalia V Simashkova, Tatiana P Klyushnik, Andrei R Grabeklis, Geir Bjørklund, Margarita G Skalnaya, Alexandr A Nikonorov, Alexey A Tinkov

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Anatoly V SkalnyAll-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia. skalny3@gmail.com.
Natalia V SimashkovaScientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Tatiana P KlyushnikScientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Andrei R GrabeklisYaroslavl State University, Yaroslavl, Russia.
Geir BjørklundCouncil for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Margarita G SkalnayaRUDN University, Moscow, Russia.
Alexandr A NikonorovOrenburg State University, Orenburg, Russia.
Alexey A TinkovOrenburg State University, Orenburg, Russia.
Mental Health Research Center of Russian Academy of Medical Sciences · RUPeoples' Friendship University of Russia · RUOrenburg State Medical Academy · RURussian New University · RUThe Research Council of Norway · NOYaroslavl State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the study was to investigate hair trace elements content in children suffering from autism spectrum disorder (ASD). A total of 74 ASD children and 74 sex- and age-matched controls divided into two age groups (2-4 and 5-9 years) were investigated. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. A general cohort of ASD children was characterized by 29 %, 41 %, and 24 % lower hair levels of chromium (Cr), iodine (I), and vanadium (V), respectively, whereas the level of selenium (Se) exceeded the respective control values by 31 %. In ASD children aged 2-4 years hair Cr, I and V content was 68 %, 36 % and 41 % lower than in the controls. Older ASD children were characterized by 45 % increase in hair Se levels. In a general cohort of ASD children hair beryllium (Be) and tin (Sn) levels were 50 % and 34 % lower than the control values. In the first age group (2-4 years) of ASD children 34 %, 42 %, and 73 % lower levels of arsenic (As), boron (B), and Be were detected. In the second age group of ASD children only a nearly significant 25 % decrease in hair lead (Pb) was detected. Surprisingly, no significant group difference in hair mercury (Hg), zinc (Zn), and copper (Cu) content was detected. Generally, the results of the present study demonstrate that children with ASD are characterized by lower values in hair of not only essential but also toxic trace elements.

Indexed as

Autism Spectrum DisorderArsenicChildChild, PreschoolChromiumCopperFemaleHairHumansIodineMaleMercurySeleniumTinTrace ElementsVanadiumArsenicChromiumCopperIodineMercurySeleniumTinTrace ElementsVanadiumZincAutismChildrenHairMetalsSeleniumTrace elements

Identifiers

PMID27581303
OpenAlexW2513818350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.