ArticleScientific reports2016
Tomographic brain imaging with nucleolar detail and automatic cell counting.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
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- 2D-3D deformable image registration of histology slide and micro-CT with DISA-based initialization.Scientific reports · 2025Article
- Synchrotron Radiation-Based Tomography of an Entire Mouse Brain with Sub-Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multi-resolution X-ray phase-contrast and dark-field tomography of human cerebellum with near-field speckles.Biomedical optics express · 2024Article
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- Distribution of corpora amylacea in the human midbrain: using synchrotron radiation phase-contrast microtomography, high-field magnetic resonance imaging, and histology.Frontiers in neuroscience · 2023Article
- Microvascular imaging of the unstained human superior colliculus using synchrotron-radiation phase-contrast microtomography.Scientific reports · 2022Article
- Non contrast enhanced volumetric histology of blood clots through high resolution propagation-based X-ray microtomography.Scientific reports · 2022Article
- Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Simultaneous 3D Visualization of the Microvascular and Neural Network in Mouse Spinal Cord Using Synchrotron Radiation Micro-Computed Tomography.Neuroscience bulletin · 2021Article
- Upscaling X-ray nanoimaging to macroscopic specimens.Journal of applied crystallography · 2021Review
- Illuminating the Brain With X-Rays: Contributions and Future Perspectives of High-Resolution Microtomography to Neuroscience.Frontiers in neuroscience · 2021Review
- Toward a scalable framework for reproducible processing of volumetric, nanoscale neuroimaging datasets.GigaScience · 2020Article
- Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.Scientific reports · 2020Article
- Assessment of plaque morphology in Alzheimer's mouse cerebellum using three-dimensional X-ray phase-based virtual histology.Scientific reports · 2020Article
- Phase-contrast x-ray tomography of neuronal tissue at laboratory sources with submicron resolution.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Ex vivo evaluation of an atherosclerotic human coronary artery via histology and high-resolution hard X-ray tomography.Scientific reports · 2019Article
- Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes.Scientific reports · 2019Article
- A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain tissue evaluation is essential for gaining in-depth insight into its diseases and disorders. Imaging the human brain in three dimensions has always been a challenge on the cell level. In vivo methods lack spatial resolution, and optical microscopy has a limited penetration depth. Herein, we show that hard X-ray phase tomography can visualise a volume of up to 43 mm(3) of human post mortem or biopsy brain samples, by demonstrating the method on the cerebellum. We automatically identified 5,000 Purkinje cells with an error of less than 5% at their layer and determined the local surface density to 165 cells per mm(2) on average. Moreover, we highlight that three-dimensional data allows for the segmentation of sub-cellular structures, including dendritic tree and Purkinje cell nucleoli, without dedicated staining. The method suggests that automatic cell feature quantification of human tissues is feasible in phase tomograms obtained with isotropic resolution in a label-free manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.