ArticleCancer causes & control : CCC2016
Association between genetic risk score for telomere length and risk of breast cancer.
Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Genetic polymorphisms affecting telomere length and their association with cardiovascular disease in the Heinz-Nixdorf-Recall study.PloS one · 2024Article
- Article
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- Genetically determined telomere length and multiple myeloma risk and outcome.Blood cancer journal · 2021Article
- Telomere Length and Male Fertility.International journal of molecular sciences · 2021Article
- Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.Journal of human genetics · 2019Article
- Association Between Leukocyte Telomere Length and Colorectal Cancer Risk in the Singapore Chinese Health Study.Clinical and translational gastroenterology · 2019Article
- Genetic variants inJournal of Cancer · 2019Article
- Mendelian randomization studies of cancer risk: a literature review.Current epidemiology reports · 2018Article
- Loss of the Association between Telomere Length and Mitochondrial DNA Copy Number Contribute to Colorectal Carcinogenesis.Pathology oncology research : POR · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeWhile leukocyte telomere length (TL) has been associated with breast cancer risk, limited information is available regarding the role of genetically-determined TL on breast cancer risk. We investigated whether aggregated TL-associated variants are associated with the risk of breast cancer in 2,865 breast cancer cases and 2,285 controls from the Shanghai Breast Cancer Genetics Study.
methodsSix genetic variants, identified through a genome-wide association study (GWAS) of TL in European-ancestry participants, were included in the study. A separate sample [n = 1,536, from the Shanghai Women's Health Study (SWHS), for whom information on both phenotypical leukocyte TL and genetic information was collected] was used to evaluate the association of six variants with TL in Asians. Three genetic risk scores (GRSs), based on the number of alleles associated with shorter TL that each individual carries for the six variants, were derived for the study: un-weighted, internally weighted (from the SWHS), and externally weighted (from the European-ancestry GWAS study), and evaluated for their association with breast cancer risk by applying logistic regression analysis.
resultsBoth internally and externally weighted GRSs were significantly associated with a decreased risk of breast cancer (OR 0.83, 95 % CI 0.72-0.95 and OR 0.84, 95 % CI 0.74-0.96, respectively, for tertile 3 vs. tertile 1). Non-genetic risk factors for breast cancer (i.e., age, years of menstruation/reproduction, oral contraceptive usage, and BMI) did not modify the association between GRSs and the risk of breast cancer.
conclusionOur results suggest that short TL, determined by genetic factors, may be associated with a reduced susceptibility to breast cancer.
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