ArticleEuropean journal of nutrition2018
Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Anti-Fatigue Effects of Donkey Milk and Its Polysaccharides in a Mouse Swimming Model.Foods (Basel, Switzerland) · 2026Article
- Special Milk and Synthetic Biology: A Dual-Perspective Review of Ingredient Substitutions in Breast-Milk-Simulated Infant Formula.Comprehensive reviews in food science and food safety · 2026Review
- Bioactive Protein Profile and Compositional Evolution of Donkey Milk Across Lactation Reflecting Its Nutritional and Functional Food Value.Foods (Basel, Switzerland) · 2025Article
- Rectal Microbiome Reveals the Improved Effect of Dietary Selenium Levels on Lactation Performance and Milk Fatty Acid Profiles in Lactating Donkeys.Animals : an open access journal from MDPI · 2025Article
- Comparative Electrophoretic Analysis Between the Protein Content in Human and Donkey Milk Samples-A Study Covering the Long-Term Lactation Period.Foods (Basel, Switzerland) · 2025Article
- Nutritional Composition and Biological Activities of Donkey Milk: A Narrative Review.Foods (Basel, Switzerland) · 2025Review
- Non-Bovine Milk as Functional Foods with Focus on Their Antioxidant and Anti-Inflammatory Bioactivities.Antioxidants (Basel, Switzerland) · 2025Review
- Protective Effects of Donkey Milk on Ethanol-Induced Gastric Ulcer in Rat.Veterinary medicine and science · 2025Article
- Commercially Purchased and In-House Bred C57BL/6 Mice with Different Gut Microbiota Exhibit Distinct Indomethacin-Induced Toxicities.Gut microbes reports · 2025Article
- Optimization ofFrontiers in microbiology · 2025Article
- Impact of intragastric administration of donkey milk on mouse immunity utilizing gut microbiomics and plasma metabolomics.Frontiers in veterinary science · 2025Article
- Donkey milk as a non-bovine alternative: a review of its nutri-functional properties, applications, and challenges.Journal of food science and technology · 2024Review
- Effects of Dietary Selenium Yeast Supplementation on Lactation Performance, Antioxidant Status, and Immune Responses in Lactating Donkeys.Antioxidants (Basel, Switzerland) · 2024Article
- Is there sufficient evidence to support the health benefits of including donkey milk in the diet?Frontiers in nutrition · 2024Review
- Influence of processing conditions on quality of Indian small grey donkey milk powder by spray drying.Journal of food science and technology · 2022Article
- The Possibility of Including Donkey Meat and Milk in the Food Chain: A Southern African Scenario.Animals : an open access journal from MDPI · 2022Review
- Identification ofFrontiers in genetics · 2022Article
- Depletion of Lipocalin 2 (LCN2) in Mice Leads to Dysbiosis and Persistent Colonization with Segmented Filamentous Bacteria.International journal of molecular sciences · 2021Article
- Current Knowledge on Functionality and Potential Therapeutic Uses of Donkey Milk.Animals : an open access journal from MDPI · 2021Review
- Insights on Health and Food Applications ofFoods (Basel, Switzerland) · 2020Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this study, we showed the beneficial effects of donkey milk (DM) on inflammatory damages, endogenous antimicrobial peptides levels and fecal microbiota profile in a mice model of Crohn's disease. Nowadays, new strategies of microbiome manipulations are on the light involving specific diets to induce and/or to maintain clinical remission. Interest of DM is explained by its high levels of antimicrobial peptides which confer it anti-inflammatory properties.
methodsC57BL/6 mice were orally administered with or without indomethacin for 5 days and co-treated with vehicle, DM or heated DM during 7 days. Intestinal length and macroscopic damage scores (MDSs) were determined; ileal samples were taken off for microscopic damage (MD), lysozyme immunostaining and mRNA α-defensin assessments. Ileal luminal content and fecal pellets were collected for lysozyme enzymatic activity and lipocalin-2 (LCN-2) evaluations. Fecal microbiota profiles were compared using a real-time quantitative PCR-based analysis.
resultsAdministration of indomethacin caused an ileitis in mice characterized by (1) a decrease in body weight and intestinal length, (2) a significant increase in MDS, MD and LCN-2, (3) a reduction in both α-defensin mRNA expression and lysozyme levels in Paneth's cells reflected by a decrease in lysozyme activity in feces, and (4) a global change in relative abundance of targeted microbial communities. DM treatment significantly reduced almost of all these ileitis damages, whereas heated DM has no impact on ileitis.
conclusionsDM consumption exerts anti-inflammatory properties in mice by restoring the endogenous levels of antimicrobial peptides which contribute in turn to reduce microbiota imbalance.
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Registered trials
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