ArticleGenes and immunity2016
Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms.
Article in Genes and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Decoupling of maternal and neonatal inflammatory levels at the maternal-fetal interface: evidence from a population-based proteomic study.Frontiers in immunology · 2026Article
- Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.Scientific reports · 2024Article
- The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents.Scientific reports · 2021Article
- Clinical characteristics of COVID-19 in children: Are they similar to those of SARS?Pediatric pulmonology · 2020Review
- Association of Maternal Factors and HIV Infection With Innate Cytokine Responses of Delivering Mothers and Newborns in Mozambique.Frontiers in microbiology · 2020Article
- Elevated Gestational IL-13 During Fetal Development Is Associated With Hyperactivity and Inattention in Eight-Year-Old Children.Frontiers in immunology · 2019Article
- Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study.PLoS neglected tropical diseases · 2018Article
- Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health.Current pathobiology reports · 2018Review
- Cytokine profiling in healthy children shows association of age with cytokine concentrations.Scientific reports · 2017Article
- Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children-A Systematic Review.Frontiers in pediatrics · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of immune responses is influenced by the interaction between environmental and genetic factors. Our previous study showed a close association between maternal and young infant's cytokine responses. The question is how this association evolves over time and the contribution of genetic polymorphisms to this association. Five cytokines in mitogen-stimulated whole blood culture were measured from pregnant mothers and their children aged 2, 5, 12, 24 and 48 months. Cytokine gene polymorphisms were determined in both mothers and children. High production of maternal interleukin (IL)-10, tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) was significantly associated with higher levels of the corresponding cytokines in their children at 2 months (T2), but the association decreased over time. Maternal single-nucleotide polymorphism (SNP) in IFN-γ gene, rs3181032, was found to be associated with child's IFN-γ levels at T2 only, whereas maternal IL-10 rs4579758 and child's TNF-α rs13215091 were associated with child's corresponding cytokines at later ages but not at T2. In the final models including the gene polymorphisms, maternal cytokines were still the strongest determinant of child cytokines. Maternal cytokine during pregnancy, which could be a proxy for child's environmental factors, showed its highest impact at early age, with no or little influence from genetic factors.
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