Evidence map›Paper›PMID 27581099›Full record

ArticleJournal of veterinary internal medicine2016

Evaluation of Serum Aspergillus-Specific Immunoglobulin A by Indirect ELISA for Diagnosis of Feline Upper Respiratory Tract Aspergillosis.

A Taylor, I Peters, N K Dhand, J Whitney, L R Johnson, J A Beatty, V R Barrs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

A TaylorFaculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia.
I PetersTDDS ltd., The Innovation Centre, University of Exeter, Devon, UK.
N K DhandFaculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia.
J WhitneyFaculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia.
L R JohnsonSchool of Veterinary Medicine, University of California, Davis, CA.
J A BeattyFaculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia.
V R BarrsFaculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia. vanessa.barrs@sydney.edu.au.
University of Sydney · AUUniversity of California, Davis · USUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerological tests for diagnosis of aspergillosis in immunocompetent humans and animals are based on Aspergillus-specific IgG (As-IgG). In humans with chronic pulmonary aspergillosis, As-IgA may be detectable even if IgG titers are negative. Cats with upper respiratory tract aspergillosis (URTA) have detectable As-IgG, but their ability to mount an IgA response and its diagnostic utility are unknown.

objectivesTo determine whether serum As-IgA can be detected in cats with URTA and evaluate its diagnostic utility alone or combined with As-IgG. ANIMALS: Twenty-three cats with URTA (Group 1), 32 cats with other respiratory diseases (Group 2), and 84 nonrespiratory controls (Group 3).

methodsSerum As-IgA and As-IgG was measured by indirect ELISA. Optimal cutoff values were determined by receiver-operating curve analysis. Sensitivity (Se) and specificity (Sp) for URTA diagnosis were determined.

resultsSerum IgA was detected in 91.3% of Group 1 cats. The Se of IgA detection was 78.3% and Sp was 96.9% for Group 2, 85.7% for Group 3 and 88.8% for Group 2 and 3 combined. Assay Se for IgG was 100% and Sp was 92.2%. Using combined IgA and IgG results at cutoffs optimized for Sp for IgA and Se for IgG and combined controls (Groups 2 and 3), Se for diagnosis was 100% and Sp was 91.4%. CONCLUSION AND CLINICAL IMPORTANCE: Most cats with URTA have serum As-IgA antibodies that can be detected by ELISA. Paired measurement of serum As-IgA and IgG shows no benefit for diagnosis of feline URTA over IgG alone.

Indexed as

AnimalsAspergillosisAspergillusCat DiseasesCatsEnzyme-Linked Immunosorbent AssayFemaleImmunoglobulin AMaleRespiratory Tract InfectionsSensitivity and SpecificityImmunoglobulin AAspergillosisAspergillusFelineSino-nasalSino-orbital

Identifiers

PMID27581099
PMCPMC5032860
OpenAlexW2507341044

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.