ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2017
Incidence and Prevalence of Achalasia in Central Chicago, 2004-2014, Since the Widespread Use of High-Resolution Manometry.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03702647 (Ropivacaine For Post-POEM Pain Control), which is not on this map. Cited by 61 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ropivacaine For Post-POEM Pain Control
Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Dietary management and feeding considerations of pediatric aerodigestive and upper gastrointestinal motility disorders.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Global trends in incidence and prevalence of achalasia, 1925-2021: A systematic review and meta-analysis.United European gastroenterology journal · 2024Pooled it
- SAGES guidelines for the use of peroral endoscopic myotomy (POEM) for the treatment of achalasia.Surgical endoscopy · 2021Guideline
- European guidelines on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations.United European gastroenterology journal · 2020Guideline
- Updated Systematic Review of Achalasia, with a Focus on POEM Therapy.Digestive diseases and sciences · 2020Pooled it
- From Pixels to Peristalsis: Comparing Achalasia Diagnosis With Artificial Intelligence With Expert Endoscopists.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Modern treatment for achalasia: endoscopic and surgical therapies.The British journal of surgery · 2026Review
- Hormone replacement therapy and the risk of achalasia in postmenopausal women: A nationwide cohort study.Medicine · 2026Article
- Idiopathic achalasia: unraveling the etiology and pathogenesis of an inflammatory disease.Gastroenterology report · 2026Review
- Esophageal myotomy and risk of esophageal cancer and mortality in achalasia: Real-world cohort study.Endoscopy international open · 2026Article
- Identification of potential drug targets for achalasia from genetic insights: a Mendelian randomization study.Journal of cardiothoracic surgery · 2025Article
- Epidemiology and practice patterns of achalasia in Taiwan: A nationwide population-based cohort study.Journal of the Chinese Medical Association : JCMA · 2025Article
- Two onset types of achalasia and the long-term course to diagnosis.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Seven-Year Experience of Intramural Surgery in the Middle East: A Safety and Feasibility Analysis.Journal of clinical medicine · 2024Article
- Concomitant Achalasia and Barrett's Esophagus: A Rare Coincidence.ACG case reports journal · 2024Article
- Altered Esophageal Smooth Muscle Phenotype in Achalasia.Journal of neurogastroenterology and motility · 2024Article
- Influence of Achalasia on the Spirometry Flow-Volume Curve and Peak Expiratory Flow.Diagnostics (Basel, Switzerland) · 2024Article
- Robotic Heller's myotomy using the new Hugo™ RAS system: first worldwide report.Surgical endoscopy · 2024Article
- Article
- Achalasia is Strongly Associated With Eosinophilic Esophagitis and Other Allergic Disorders.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
1 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
BACKGROUND &
aimsReported global incidence and prevalence values for achalasia vary widely, from 0.03 to 1.63 per 100,000 persons per year and from 1.8 to 12.6 per 100,000 persons per year, respectively. This study aimed to reconcile these low values with findings from a major referral center, in central Chicago (which began using high-resolution manometry in 2004 and used it in all clinical studies since 2005), and has determined the incidence and prevalence of achalasia to be much greater.
methodsWe collected data from the Northwestern Medicine Enterprise Data Warehouse database (tertiary care setting) of adults residing in Chicago with an encounter diagnosis of achalasia from 2004 through 2014. Patient files were reviewed to confirm diagnosis and residential address. US Census Bureau population data were used as the population denominator. We assumed that we encountered every incident case in the city to calculate incidence and prevalence estimates. Data were analyzed for the city at large and for the 13 zip codes surrounding the Northwestern Memorial Hospital (NMH), the NMH neighborhood.
resultsWe identified 379 cases (50.9% female) that met the full inclusion criteria; of these, 246 were incident cases. Among these, 132 patients resided in the NMH neighborhood, 89 of which were incident cases. Estimated yearly incidences were stable over the study period, ranging from 0.77 to 1.35 per 100,000 citywide (average, 1.07 per 100,000) and from 1.41 to 4.60 per 100,000 in the NMH neighborhood (average, 2.92 per 100,000). The corresponding prevalence values increased progressively, from 4.68 to 14.42 per 100,000 citywide and from 15.64 to 32.58 per 100,000 in the NMH neighborhood.
conclusionsThe incidence and prevalence of achalasia in central Chicago diagnosed using state-of-the-art technology and diagnostic criteria are at least 2- to 3-fold greater than previous estimates. Additional studies are needed to determine the generalizability of these data to other regions.
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