Evidence map›Paper›PMID 27580886›Full record

ArticleTemperature (Austin, Tex.)

Neural control of inflammation by the greater splanchnic nerves.

Davide Martelli, Song T Yao, Michael J McKinley, Robin M McAllen

Abstract readComment
In one paragraph

Article in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
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  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Davide MartelliFlorey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Biomedical and Neuromotor Science; University of Bologna; Bologna, Italy.
Song T YaoFlorey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia.
Michael J McKinleyFlorey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Physiology; University of Melbourne; Parkville, Australia.
Robin M McAllenFlorey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Anatomy and Neuroscience; University of Melbourne; Parkville, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain influences immune function through a powerful neural reflex that suppresses the release of a key pro-inflammatory cytokine, tumor necrosis factor α, after immune challenge. The efferent motor pathway of this reflex is in the splanchnic nerves, not the vagi. This reflex regulates inflammation but does not suppress fever.

Indexed as

endotoxemiafevergreater splanchnic nerveinflammationlipopolysaccharide (LPS)sympathetic nervous systemtumor necrosis factor α (TNFα)vagus nerve

Identifiers

PMID27580886
PMCPMC4972513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.