Evidence map›Paper›PMID 27580825›Full record

ArticleBMJ open2016

Challenges in collecting clinical samples for research from pregnant women of South Asian origin: evidence from a UK study.

Sharmind Neelotpol, Alastair W M Hay, A Jim Jolly, Mike W Woolridge

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Sharmind NeelotpolDepartment of Pharmacy, BRAC University, Dhaka, Bangladesh.
Alastair W M HayDepartment of Environmental Toxicology, School of Medicine, University of Leeds, Leeds, UK.
A Jim JollySchool of Healthcare, University of Leeds, Leeds, UK.
Mike W WoolridgeUCL Institute of Child Health, London, UK.
University of Leeds · GBBRAC University · BDUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo recruit South Asian pregnant women, living in the UK, into a clinicoepidemiological study for the collection of lifestyle survey data and antenatal blood and to retain the women for the later collection of cord blood and meconium samples from their babies for biochemical analysis.

designA longitudinal study recruiting pregnant women of South Asian and Caucasian origin living in the UK.

settingRecruitment of the participants, collection of clinical samples and survey data took place at the 2 sites within a single UK Northern Hospital Trust.

participantsPregnant women of South Asian origin (study group, n=98) and of Caucasian origin (comparison group, n=38) living in Leeds, UK.

resultsAmong the participants approached, 81% agreed to take part in the study while a 'direct approach' method was followed. The retention rate of the participants was a remarkable 93.4%. The main challenges in recruiting the ethnic minority participants were their cultural and religious conservativeness, language barrier, lack of interest and feeling of extra 'stress' in taking part in research. The chief investigator developed an innovative participant retention method, associated with the women's cultural and religious practices. The method proved useful in retaining the participants for about 5 months and in enabling successful collection of clinical samples from the same mother-baby pairs. The collection of clinical samples and lifestyle data exceeded the calculated sample size required to give the study sufficient power. The numbers of samples obtained were: maternal blood (n=171), cord blood (n=38), meconium (n=176), lifestyle questionnaire data (n=136) and postnatal records (n=136).

conclusionsRecruitment and retention of participants, according to the calculated sample size, ensured sufficient power and success for a clinicoepidemiological study. Results suggest that development of trust and confidence between the participant and the researcher is the key to the success of a clinical and epidemiological study involving ethnic minorities.

Indexed as

Biomedical ResearchPatient SelectionAdultAsian PeopleBlood Specimen CollectionCommunication BarriersCultureFemaleFetal BloodHumansLife StyleLongitudinal StudiesMeconiumMiddle AgedPregnancyReligionEPIDEMIOLOGYPUBLIC HEALTHSouth Asian, recruitment, retention, ante-natal blood, meconium, clinico-epidemiology.

Identifiers

PMID27580825
PMCPMC5013462
OpenAlexW2514166898

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.