ArticleJournal of anatomy2017
A resegmentation-shift model for vertebral patterning.
Article in Journal of anatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Congenital and Breed-Associated Vertebral Anomalies in Dogs and Cats: Developmental Anatomy, Genetic Determinants, and Biological Significance.Life (Basel, Switzerland) · 2026Review
- The notochord: development, disease and stem cell-based modelling.Development (Cambridge, England) · 2026Review
- Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Modularity and integration of the neural arch and vertebral centrum in primates.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Review of the tetrapod skull-neck boundary: implications for the evolution of the atlas-axis complex.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Craniospinal space reduction and malalignment due to atlas assimilation in Basilar Invagination-A case-control study.World neurosurgery: X · 2025Article
- Development and Degeneration of the Intervertebral Disc-Insights from Across Species.Veterinary sciences · 2023Review
- Intravertebral vs. intervertebral integration and modularity in the vertebral column of mammalian carnivorans.Journal of anatomy · 2023Article
- TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.Developmental biology · 2022Article
- Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.Journal of anatomy · 2022Review
- Theories, laws, and models in evo-devo.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- Development and evolution of the tetrapod skull-neck boundary.Biological reviews of the Cambridge Philosophical Society · 2020Review
- Article
- Development of the axial skeleton and intervertebral disc.Current topics in developmental biology · 2019Review
- IVD Development: Nucleus pulposus development and sclerotome specification.Current molecular biology reports · 2018Article
- The role of the notochord in amniote vertebral column segmentation.Developmental biology · 2018Article
- Spine Patterning Is Guided by Segmentation of the Notochord Sheath.Cell reports · 2018Article
- Closure of the vertebral canal in human embryos and fetuses.Journal of anatomy · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Segmentation of the vertebrate body axis is established in the embryo by formation of somites, which give rise to the axial muscles (myotome) and vertebrae (sclerotome). To allow a muscle to attach to two successive vertebrae, the myotome and sclerotome must be repositioned by half a segment with respect to each other. Two main models have been put forward: 'resegmentation' proposes that each half-sclerotome joins with the half-sclerotome from the next adjacent somite to form a vertebra containing cells from two successive somites on each side of the midline. The second model postulates that a single vertebra is made from a single somite and that the sclerotome shifts with respect to the myotome. There is conflicting evidence for these models, and the possibility that the mechanism may vary along the vertebral column has not been considered. Here we use DiI and DiO to trace somite contributions to the vertebrae in different axial regions in the chick embryo. We demonstrate that vertebral bodies and neural arches form by resegmentation but that sclerotome cells shift in a region-specific manner according to their dorsoventral position within a segment. We propose a 'resegmentation-shift' model as the mechanism for amniote vertebral patterning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.