ArticleBMC genetics2016
Evaluation of forensic DNA mixture evidence: protocol for evaluation, interpretation, and statistical calculations using the combined probability of inclusion.
Article in BMC genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Applicability of imprinted DIP-SNP markers in DNA mixture analysis: a pilot study.International journal of legal medicine · 2026Article
- A novel 16-plex DIP-SNP panel for forensic analysis of imbalanced DNA mixtures in a Han Chinese population.International journal of legal medicine · 2026Article
- Autosomal STR Markers for Forensic Genetics: Applications, Challenges, and Future Directions.Genes · 2026Review
- Reanalyzing DNA mixture: a evaluation of EuroForMix for deconvolution and weight-of-evidence computing.Forensic science, medicine, and pathology · 2025Article
- Validation of the EuroForMix at the Brazilian Federal Police: Analysis of matches involving complex genetic profiles.Forensic science international. Synergy · 2025Article
- Review
- Article
- Decreased accuracy of forensic DNA mixture analysis for groups with lower genetic diversity.iScience · 2024Article
- Dense single nucleotide polymorphism testing revolutionizes scope and degree of certainty for source attribution in forensic investigations.Croatian medical journal · 2024Review
- Article
- Human complex mixture analysis by "FD Multi-SNP Mixture Kit".Frontiers in genetics · 2024Article
- DNAmix 2021: Laboratory policies, procedures, and casework scenarios summary and dataset.Data in brief · 2023Article
- Improving the Utilization of STRmix™ Variance Parameters as Semi-Quantitative Profile Modeling Metrics.Genes · 2022Article
- A new implementation of a semi-continuous method for DNA mixture interpretation.Forensic Science International. Reports · 2022Article
- Use of hormone-specific antibody probes for differential labeling of contributor cell populations in trace DNA mixtures.International journal of legal medicine · 2022Article
- Article
- A New Computational Deconvolution Algorithm for the Analysis of Forensic DNA Mixtures with SNP Markers.Genes · 2022Article
- Development and validation of a novel 133-plex forensic STR panel (52 STRs and 81 Y-STRs) using single-end 400 bp massive parallel sequencing.International journal of legal medicine · 2022Article
- Evaluating Mixture Solution™- rapid and non-MCMC probabilistic mixture analysis.International journal of legal medicine · 2021Article
- Developments in forensic DNA analysis.Emerging topics in life sciences · 2021Review
Corrections and comments
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evaluation and interpretation of forensic DNA mixture evidence faces greater interpretational challenges due to increasingly complex mixture evidence. Such challenges include: casework involving low quantity or degraded evidence leading to allele and locus dropout; allele sharing of contributors leading to allele stacking; and differentiation of PCR stutter artifacts from true alleles. There is variation in statistical approaches used to evaluate the strength of the evidence when inclusion of a specific known individual(s) is determined, and the approaches used must be supportable. There are concerns that methods utilized for interpretation of complex forensic DNA mixtures may not be implemented properly in some casework. Similar questions are being raised in a number of U.S. jurisdictions, leading to some confusion about mixture interpretation for current and previous casework.
resultsKey elements necessary for the interpretation and statistical evaluation of forensic DNA mixtures are described. Given the most common method for statistical evaluation of DNA mixtures in many parts of the world, including the USA, is the Combined Probability of Inclusion/Exclusion (CPI/CPE). Exposition and elucidation of this method and a protocol for use is the focus of this article. Formulae and other supporting materials are provided.
conclusionsGuidance and details of a DNA mixture interpretation protocol is provided for application of the CPI/CPE method in the analysis of more complex forensic DNA mixtures. This description, in turn, should help reduce the variability of interpretation with application of this methodology and thereby improve the quality of DNA mixture interpretation throughout the forensic community.
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