Evidence map›Paper›PMID 27580518›Full record

ArticleMagnetic resonance imaging2017

Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T.

Matthew S Davitz, William E Wu, Brian J Soher, James S Babb, Ivan I Kirov, Jeffrey Huang, Girish Fatterpekar, Oded Gonen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew S DavitzCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
William E WuCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Brian J SoherDepartment of Radiology, Duke University Medical Center, Durham, NC, 27710, USA.
James S BabbCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Ivan I KirovCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Jeffrey HuangCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Girish FatterpekarCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Oded GonenCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: oded.gonen@med.nyu.edu.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
HIGHER SPEED, FIELD &SPATIAL RESOLUTION BRAIN 3D 1H MRSR01EB001015 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GONEN, ODED · 2002 to 2011
$5.8M
Spectroscopic imaging of human epilepsyR01NS090417 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAN, JULLIE W · 2014 to 2017
$2.4M
Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain InjuryR01NS097494 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIROV, IVAN IVANOV, MADELIN, GUILLAUME · 2016 to 2020
$2.4M
7T MR spectroscopic imaging for human epilepsyR01EB011639 · NIBIB · YALE UNIVERSITY · PI HETHERINGTON, HOBY P, PAN, JULLIE W · 2011 to 2014
$2.0M
Multiplexed Multiband MR at 7T: Studies of mild Traumatic Brain InjuryR01NS081772 · NINDS · YALE UNIVERSITY · PI HETHERINGTON, HOBY P · 2012 to 2015
$2.0M
MrSPA: Integrated tools and development platform for magnetic resonance researchR01EB008387 · NIBIB · DUKE UNIVERSITY · PI SOHER, BRIAN J, YOUNG, KARL A · 2008 to 2010
$1.2M
NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB001015NIBIB NIH HHS R01 EB008387NIBIB NIH HHS R01 EB011639NINDS NIH HHS R01 NS081772NINDS NIH HHS R01 NS090417NINDS NIH HHS R01 NS097494
6 · The paper itself

Abstract

background and purposeTo assess the sensitivity of non-localized, whole-head MATERIALS AND

methodsIn this prospective study, four back-to-back (single imaging session) and three serial (successive sessions) non-localizing, ~3min

resultsThe intra-scan CVs for the NAA, Glx, Cr and Cho were: 3.9±1.8%, 7.3±4.6%, 4.0±3.4% and 2.5±1.6%, and the corresponding inter-scan (longitudinal) values were: 7.0±3.1%, 10.6±5.6%, 7.6±3.5% and 7.0±3.9%. This method is shown to have 80% power to detect changes of 14%, 27%, 26% and 19% between two serial measurements in a given individual.

conclusionsSubject to the assumption that in neurological disorders NAA, Glx, Cr and Cho changes represent brain-only pathology and not muscles, bone marrow, adipose tissue or epithelial cells, this approach enables us to quantify them, thereby adding specificity to the assessment of the total disease load. This will facilitate monitoring diffuse pathologies with faster measurement, more extensive (~90% of the brain) spatial coverage and sensitivity than localized

Indexed as

AdolescentAdultAspartic AcidBrainCholineCreatineFemaleGlutamic AcidGlutamineHumansMaleProspective StudiesProton Magnetic Resonance SpectroscopyReference ValuesReproducibility of ResultsSensitivity and SpecificityAspartic AcidCholineCreatineGlutamic AcidGlutamineN-acetylaspartateDiffuse neurological disordersMetabolic quantificationMR spectroscopyProton MR spectroscopyWhole brain MR spectroscopy

Identifiers

PMID27580518
PMCPMC5125897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.