Evidence map›Paper›PMID 27580061›Full record

SynthesisCardiovascular therapeutics2017

Colchicine for prevention and treatment of cardiac diseases: A meta-analysis.

Nikolaos Papageorgiou, Alexandros Briasoulis, George Lazaros, Massimo Imazio, Dimitris Tousoulis

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Cardiovascular therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04056039 phase2completedstarted 2018, after this paper: background citation

Efficacy of Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity as a Biomarker of Myocardial Damage in Patients With Rheumatoid Arthritis With Severe Activity.

Ran2018Enrolled60Registered outcomes3Posted comparisons0ConditionsArthritis, Rheumatoid, Cardiovascular DiseasesArmsAtorvastatin, Colchicine
PMID 18926169PMID 29554376PMID 29417936PMID 29353098PMID 29352092PMID 29331272PMID 29322198PMID 28610589PMID 27965879PMID 25662717PMID 25533796PMID 24820145other papers from this trial
Open the trial in the graph
NCT04139655 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study (COPMAN)

TypeinterventionalSponsorUniversity of British ColumbiaRan2020 to 2021Enrolled0ConditionsMyocardial Infarction, Myocardial Injury, Major Adverse Cardiac Events, Infectious ComplicationsArmsColchicine 0.6 mg, Placebo oral tablet
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Colchicine for the primary prevention of cardiovascular events.The Cochrane database of systematic reviews · 2025
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  15. Effusive-constrictive pericarditis as first manifestation of late-onset systemic lupus erythematosus: an atypical case with grave prognosis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Nikolaos PapageorgiouBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Alexandros BriasoulisCardiovascular Institute, Wayne State University, Detroit, MI, USA.
George LazarosFirst Cardiology Department, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.
Massimo ImazioCardiology Department, Maria Vittoria Hospital, Torino, Italy.
Dimitris TousoulisFirst Cardiology Department, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.
Hippocration General Hospital · GROspedale Maria Vittoria · ITSt Bartholomew's Hospital · GBWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsColchicine has been suggested to be beneficial in preventing recurrent pericarditis. The goal of this study was to review all randomized controlled trials that assess the use of colchicine for the prevention and treatment of cardiac diseases.

methodsWe performed a meta-analysis of the effects of colchicine on pericarditis, postpericardiotomy syndrome and postprocedural atrial fibrillation recurrence, in-stent restenosis, gastrointestinal adverse effects, and treatment discontinuation rates. We conducted an EMBASE and MEDLINE search for prospective controlled trials.

resultsWe identified 17 prospective controlled randomized studies with 2082 patients that received colchicine and 1982 controls with an average follow-up duration of 12 months. Treatment with colchicine is associated with reduced risk of pericarditis recurrence/postpericardiotomy syndrome (OR: 0.37; 95% CI: 0.29-0.47; P<0.001) and lower recurrence of atrial fibrillation rates after cardiac surgery and ablation procedures. However, gastrointestinal side effects were more common in patients treated with colchicine (OR: 2.6; 95% CI: 1.82-3.72; P<0.001) in all subgroups except for those treated for prevention of recurrent pericarditis. The higher rates of side effects resulted in higher incidence of treatment discontinuation in patients treated with colchicine.

conclusionColchicine appears to be efficacious and well tolerated for recurrent pericarditis/postpericardiotomy syndrome and recurrence of postprocedural atrial fibrillation. However, its efficacy may be limited by its gastrointestinal adverse events and treatment discontinuation rates particularly in postoperative patients.

Indexed as

AgedCardiovascular AgentsChi-Square DistributionColchicineGastrointestinal DiseasesHeart DiseasesHumansMiddle AgedOdds RatioRisk FactorsTreatment OutcomeCardiovascular AgentsColchicineAtrial fibrillationColchicineCoronary artery diseaseGastrointestinal side effectsPericarditisPost-pericardiotomy syndrome

Identifiers

PMID27580061
OpenAlexW2513111397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.