ArticleMagnetic resonance in medicine2017
Double oscillating diffusion encoding and sensitivity to microscopic anisotropy.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects.NeuroImage · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Mapping complex cell morphology in the grey matter with double diffusion encoding MR: A simulation study.NeuroImage · 2021Article
- Review
- Article
- A simple estimate of axon size with diffusion MRI.NeuroImage · 2021Article
- The sensitivity of diffusion MRI to microstructural properties and experimental factors.Journal of neuroscience methods · 2021Review
- Microscopic anisotropy misestimation in spherical-mean single diffusion encoding MRI.Magnetic resonance in medicine · 2019Article
- Relevance of time-dependence for clinically viable diffusion imaging of the spinal cord.Magnetic resonance in medicine · 2019Article
- In vivo microscopic diffusional kurtosis imaging with symmetrized double diffusion encoding EPI.Magnetic resonance in medicine · 2019Article
- Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue.Scientific reports · 2018Article
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Authors and funding
4 authors.
Funding
Abstract
purposeTo introduce a novel diffusion pulse sequence, namely double oscillating diffusion encoding (DODE), and to investigate whether it adds sensitivity to microscopic diffusion anisotropy (µA) compared to the well-established double diffusion encoding (DDE) methodology.
methodsWe simulate measurements from DODE and DDE sequences for different types of microstructures exhibiting restricted diffusion. First, we compare the effect of varying pulse sequence parameters on the DODE and DDE signal. Then, we analyse the sensitivity of the two sequences to the microstructural parameters (pore diameter and length) which determine µA. Finally, we investigate specificity of measurements to particular substrate configurations.
resultsSimulations show that DODE sequences exhibit similar signal dependence on the relative angle between the two gradients as DDE sequences, however, the effect of varying the mixing time is less pronounced. The sensitivity analysis shows that in substrates with elongated pores and various orientations, DODE sequences increase the sensitivity to pore diameter, while DDE sequences are more sensitive to pore length. Moreover, DDE and DODE sequence parameters can be tailored to enhance/suppress the signal from a particular range of substrates.
conclusionsA combination of DODE and DDE sequences maximize sensitivity to µA, compared to using just the DDE method. Magn Reson Med 78:550-564, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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