ArticleCell cycle (Georgetown, Tex.)2016
Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- High Mobility Group Proteins in Sepsis.Frontiers in immunology · 2022Review
- Integrated Analysis of Multiple Microarrays Based on Raw Data Identified Novel Gene Signatures in Recurrent Implantation Failure.Frontiers in endocrinology · 2022Article
- Loss of miR-29a impairs decidualization of endometrial stromal cells by TET3 mediated demethylation of Col1A1 promoter.iScience · 2021Article
- Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Identification of mRNAs related to endometrium function regulated by lncRNA CD36-005 in rat endometrial stromal cells.Reproductive biology and endocrinology : RB&E · 2018Article
- Loss of high-mobility group N5 contributes to the promotion of human endometrial stromal cell decidualization.Reproductive medicine and biology · 2018Article
- IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation.Cell cycle (Georgetown, Tex.) · 2017Article
- Expression and regulation of Angiopoietins and their receptor Tie-2 in sika deer antler.Animal cells and systems · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Hmgn5 is involved in the regulation of cellular proliferation and differentiation, its physiological function during decidualization is still unknown. Here we showed that Hmgn5 was highly expressed in the decidual cells. Silencing of Hmgn5 expression by specific siRNA reduced the proliferation of uterine stromal cells and expression of Ccnd3 and Cdk4 in the absence or presence of estrogen and progesterone, whereas overexpression of Hmgn5 exhibited the opposite effects. Simultaneously, Hmgn5 might induce the expression of Prl8a2 and Prl3c1 which were 2 well-known differentiation markers for decidualization. In the uterine stromal cells, cAMP analog 8-Br-cAMP and progesterone could up-regulate the expression of Hmgn5, but the up-regulation was impeded by H89 and RU486, respectively. Attenuation of Hmgn5 expression could block the differentiation of uterine stromal cells in response to cAMP and progesterone. Further studies found that regulation of cAMP and progesterone on Hmgn5 expression was mediated by Hoxa10. During in vitro decidualization, knockdown of Hmgn5 could abrogate Hoxa10-induced upregulation of Prl8a2 and Prl3c1, while overexpression of Hmgn5 reversed the inhibitory effects of Hoxa10 siRNA on the expression of Prl8a2 and Prl3c1. In the stromal cells undergoing decidualization, Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. Collectively, Hmgn5 may play an important role during mouse decidualization.
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