Evidence map›Paper›PMID 27579858›Full record

ArticleMucosal immunology2017

Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV.

M Rodriguez-Garcia, Z Shen, F D Barr, A W Boesch, M E Ackerman, J C Kappes, C Ochsenbauer, C R Wira

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

M Rodriguez-GarciaDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Z ShenDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
F D BarrDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
A W BoeschThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
M E AckermanThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
J C KappesDepartment of Medicine and UAB Center for AIDS Research, University of Alabama at Birmingham, Research Service Birmingham, Birmingham, Alabama, USA.
C OchsenbauerDepartment of Medicine and UAB Center for AIDS Research, University of Alabama at Birmingham, Research Service Birmingham, Birmingham, Alabama, USA.
C R WiraDepartment of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Dartmouth College · USBirmingham VA Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Training Program in Pathophysiology of Solid TumorsT32CA073479 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 1998 to 2012
$3.0M
Chemical Contraceptive Control of Microbicides in the Female Reproductive TractR01AI117739 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2015 to 2018
$2.6M
Menstrual Cycle Control of HIV Infection in the Reproductive TractR01AI102838 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2012 to 2016
$2.2M
NCI NIH HHS P30 CA023108NCI NIH HHS T32 CA073479NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI102838NIAID NIH HHS R01 AI117739
6 · The paper itself

Abstract

Dendritic cells (DCs) throughout the female reproductive tract (FRT) were examined for phenotype, HIV capture ability and innate anti-HIV responses. Two main CD11c

Indexed as

Immunity, InnateCD11c AntigenCell Adhesion MoleculesCells, CulturedChemokine CCL2DC-Specific ICAM-3 Grabbing NonintegrinDendritic CellsElafinEstradiolFemaleGenitalia, FemaleHIVHIV InfectionsHumansInterleukin-8Lectins, C-TypeCCR5 protein, humanCD11c AntigenCell Adhesion MoleculesChemokine CCL2DC-Specific ICAM-3 Grabbing NonintegrinElafinEstradiolInterleukin-8Lectins, C-TypeLipopolysaccharide ReceptorsReceptors, CCR5Receptors, Cell SurfaceSecretory Leukocyte Peptidase InhibitorSLPI protein, human

Identifiers

PMID27579858
PMCPMC5332537
OpenAlexW2513610200

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.