ArticlePloS one2016
A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage.Computers in biology and medicine · 2026Article
- Next-generation osteoarthritis models: integrating biological, computational, and engineering approaches.Stem cell research & therapy · 2025Review
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- Immune digital twins for complex human pathologies: applications, limitations, and challenges.NPJ systems biology and applications · 2024Review
- Recent Advances in Liver Tissue Engineering as an Alternative and Complementary Approach for Liver Transplantation.Current issues in molecular biology · 2023Review
- Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology.Advanced healthcare materials · 2023Article
- Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis.Frontiers in bioengineering and biotechnology · 2023Article
- An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis.BMC biology · 2022Article
- Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments.Scientific reports · 2022Article
- Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells.Cell and tissue research · 2021Article
- Simulating intervertebral disc cell behaviour within 3D multifactorial environments.Bioinformatics (Oxford, England) · 2021Article
- Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.Advanced drug delivery reviews · 2021Review
- An ECHO of Cartilage:Frontiers in bioengineering and biotechnology · 2021Article
- Use of Computational Modeling to Study Joint Degeneration: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2018Review
- Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
Differentiation of chondrocytes towards hypertrophy is a natural process whose control is essential in endochondral bone formation. It is additionally thought to play a role in several pathophysiological processes, with osteoarthritis being a prominent example. We perform a dynamic analysis of a qualitative mathematical model of the regulatory network that directs this phenotypic switch to investigate the influence of the individual factors holistically. To estimate the stability of a SOX9 positive state (associated with resting/proliferation chondrocytes) versus a RUNX2 positive one (associated with hypertrophy) we employ two measures. The robustness of the state in canalisation (size of the attractor basin) is assessed by a Monte Carlo analysis and the sensitivity to perturbations is assessed by a perturbational analysis of the attractor. Through qualitative predictions, these measures allow for an in silico screening of the effect of the modelled factors on chondrocyte maintenance and hypertrophy. We show how discrepancies between experimental data and the model's results can be resolved by evaluating the dynamic plausibility of alternative network topologies. The findings are further supported by a literature study of proposed therapeutic targets in the case of osteoarthritis.
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Registered trials
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