ArticlePloS one2016
Northern Latitude but Not Season Is Associated with Increased Rates of Hospitalizations Related to Inflammatory Bowel Disease: Results of a Multi-Year Analysis of a National Cohort.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of autoimmune diseases is strongly associated with average annual temperatures: systematic review and linear regression analysis.BMC rheumatology · 2025Pooled it
- Pooled it
- Quantum Effects in Evolution: Terrestrial Fine-Tuning of Magnetic Parameters.Computational and structural biotechnology journal · 2026Article
- Prevalence of cataract and its contributing factors in Iranian elderly population: the Gilan eye study.International ophthalmology · 2023Article
- Review article: Becoming and being coeliac-special considerations for childhood, adolescence and beyond.Alimentary pharmacology & therapeutics · 2022Review
- FODMAPs, inflammatory bowel disease and gut microbiota: updated overview on the current evidence.European journal of nutrition · 2022Review
- The Association of Latitude and Altitude with COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis.The open respiratory medicine journal · 2022Article
- Microscopic colitis in older adults: impact, diagnosis, and management.Therapeutic advances in chronic disease · 2022Review
- Acute Ischemic Stroke Interventions in the United States and Racial, Socioeconomic, and Geographic Disparities.Neurology · 2021Article
- The weekend effect does not influence management of inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Mortality and Hospitalizations in Mexican Patients with Inflammatory Bowel Disease: Results from a Nationwide Health Registry.Canadian journal of gastroenterology & hepatology · 2020Article
- Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease.Gastroenterology clinics of North America · 2017Review
- Purinergic signaling during intestinal inflammation.Journal of molecular medicine (Berlin, Germany) · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
aimsThere is growing evidence that the incidence and severity of inflammatory bowel disease (IBD) may be geographically and seasonally related. Why these associations are observed remains unclear. We assessed the impact of geographic location, season, and exposure to ultraviolet light on disease severity by measuring national hospital IBD-related discharge rates.
methodsUtilizing the Nationwide Inpatient Sample (NIS), we identified all patients with IBD-related discharges from 2001-2007. Patients were included if they were discharged from states above the 40th parallel (north) or at or below the 35th parallel (south); and their discharge fell within the winter (January, February, and March) or summer (July, August, and September). Groups of patients were assessed comparing north to south within each season, and summer to winter within each region. UV index was recorded from the National Weather Service data and compared to monthly discharge rates.
resultsThere was a consistent pattern of increased IBD-related hospitalization rates in northern states compared to southern states for both ulcerative colitis and Crohn's disease. Differences in IBD-related hospitalization rates by season, however, were not uniform across the years studied. UV index was significantly inversely associated although not proportional to discharge rates for both Crohn's disease and ulcerative colitis.
conclusionsIn the US, there is a significant increased rate of IBD-related hospitalizations in the northern compared to southern states, which not fully explained by differences in UV exposure.
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