Evidence map›Paper›PMID 27579698›Full record

ArticlePloS one2016

Mouse Models of Diabetes, Obesity and Related Kidney Disease.

Sarah J Glastras, Hui Chen, Rachel Teh, Rachel T McGrath, Jason Chen, Carol A Pollock, Muh Geot Wong, Sonia Saad

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
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  8. Metabolic and Antioxidant Modulation byInternational journal of molecular sciences · 2025
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  11. SerpinA3k Deficiency Ameliorates Experimental type 2 Diabetes.Cellular and molecular life sciences : CMLS · 2025
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  12. Article
  13. Upregulation of Piezo2 and increased extracellular matrix protein in diabetic kidney disease mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sarah J GlastrasDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
Rachel TehDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Rachel T McGrathDepartment of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
Jason ChenDepartment of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.
Carol A PollockDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Muh Geot WongDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Sonia SaadDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
University of Sydney · AURoyal North Shore Hospital · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple rodent models have been used to study diabetic kidney disease (DKD). The purpose of the present study was to compare models of diabetes and obesity-induced metabolic syndrome and determine differences in renal outcomes. C57BL/6 male mice were fed either normal chow or high fat diet (HFD). At postnatal week 8, chow-fed mice were randomly assigned to low-dose streptozotocin (STZ, 55 mg/kg/day, five consecutive days) or vehicle control, whereas HFD-fed mice were given either one high-dose of STZ (100 mg/kg) or vehicle control. Intraperitoneal glucose tolerance tests were performed at Week 14, 20 and 30. Urinary albumin to creatinine ratio (ACR) and serum creatinine were measured, and renal structure was assessed using Periodic Acid Schiff (PAS) staining at Week 32. Results showed that chow-fed mice exposed to five doses of STZ resembled type 1 diabetes mellitus with a lean phenotype, hyperglycaemia, microalbuminuria and increased serum creatinine levels. Their kidneys demonstrated moderate tubular injury with evidence of tubular dilatation and glycogenated nuclear inclusion bodies. HFD-fed mice resembled metabolic syndrome as they were obese with dyslipidaemia, insulin resistance, and significantly impaired glucose tolerance. One dose STZ, in addition to HFD, did not worsen metabolic features (including fasting glucose, non esterified fatty acid, and triglyceride levels). There were significant increases in urinary ACR and serum creatinine levels, and renal structural changes were predominantly related to interstitial vacuolation and tubular dilatation in HFD-fed mice.

Indexed as

Disease Models, AnimalAlbuminsAnimalsBlood GlucoseCreatinineDiabetes Mellitus, ExperimentalDiabetic NephropathiesDiet, High-FatGlucose Tolerance TestHumansKidneyMiceMice, Inbred C57BLObesityRandom AllocationStreptozocinAlbuminsBlood GlucoseCreatinineStreptozocin

Identifiers

PMID27579698
PMCPMC5006968
OpenAlexW2511211800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.