ArticlePloS one2016
Distinct Small RNA Signatures in Extracellular Vesicles Derived from Breast Cancer Cell Lines.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-omic profiling of early pregnancy small and large plasma extracellular vesicles reveals placental, metabolic, and structural adaptation signatures.bioRxiv : the preprint server for biology · 2026Article
- Deciphering the Functional Status of Breast Cancers through the Analysis of Their Extracellular Vesicles.International journal of molecular sciences · 2023Review
- Article
- 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Exosome-like Vesicles ofInternational journal of molecular sciences · 2023Article
- Assessing Breast Cancer Molecular Subtypes Using Extracellular Vesicles' mRNA.Analytical chemistry · 2023Article
- Emerging function and clinical significance of extracellular vesicle noncoding RNAs in lung cancer.Molecular therapy oncolytics · 2022Review
- Extracellular vesicles derived from radioresistant oral squamous cell carcinoma cells contribute to the acquisition of radioresistance via the miR-503-3p-BAK axis.Journal of extracellular vesicles · 2021Article
- Distinct Extracellular RNA Profiles in Different Plasma Components.Frontiers in genetics · 2021Article
- Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis.BioMed research international · 2021Review
- Stumbling on elusive cargo: how isomiRs challenge microRNA detection and quantification, the case of extracellular vesicles.Journal of extracellular vesicles · 2020Article
- Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer.Journal of cell science · 2019Review
- 3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Cancer cells exploit an orphan RNA to drive metastatic progression.Nature medicine · 2018Article
- Small non-coding RNA landscape of extracellular vesicles from human stem cells.Scientific reports · 2018Article
- Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells.Cellular and molecular life sciences : CMLS · 2018Article
- The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications.Cells · 2018Review
- Ultrasound-guided intertumoral injection of contrast agents combined with human p53 gene for the treatment of breast cancer.The Kaohsiung journal of medical sciences · 2018Article
- Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome.Scientific reports · 2018Article
- Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer.Molecular therapy. Nucleic acids · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules have gained much attention as players in intercellular communication, ability to precondition specific organs for metastatic invasion, and for their potential role as circulating cancer biomarkers. EVs are released from the cells and contain proteins, DNA, and long and small RNA species. Here we show by high-throughput small RNA-sequencing that EVs from nine different breast cancer cell lines share common characteristics in terms of small RNA content that are distinct from their originating cells. Most strikingly, a highly abundant small RNA molecule derived from the nuclear 28S rRNA is vastly enriched in EVs. The miRNA profiles in EVs correlate with the cellular miRNA expression pattern, but with a few exceptions that includes miR-21. This cancer-associated miRNA is retained in breast cancer cell lines. Finally, we report that EVs from breast cancer cell lines cluster together based on their small RNA signature when compared to EVs derived from other cancer cell lines. Altogether, our data demonstrate that breast cancer cell lines manifest a specific small RNA signature in their released EVs. This opens up for further evaluation of EVs as breast cancer biomarkers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.