Evidence map›Paper›PMID 27579566›Full record

ArticleMagnetic resonance in medicine2017

Creatine kinase rate constant in the human heart measured with 3D-localization at 7 tesla.

William T Clarke, Matthew D Robson, Stefan Neubauer, Christopher T Rodgers

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Repeatability of Rapid Human Cardiac Phosphorus MRSI (Magnetic resonance in medicine · 2026
    Article
  2. Review
  3. CardiacHeart failure reviews · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Cardiac work is related to creatine kinase energy supply in human heart failure: a cardiovascular magnetic resonance spectroscopy study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
    Article
  13. Review
  14. In-vivoAnalytical biochemistry · 2017
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

William T ClarkeOxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.ORCID 0000-0001-7159-7025
Matthew D RobsonOxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Stefan NeubauerOxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Christopher T RodgersOxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
John Radcliffe Hospital · GB

Funding

Medical Research Council G0900883Wellcome Trust 098436/Z/12/Z
6 · The paper itself

Abstract

purposeWe present a new Bloch-Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first-order effective rate constant k

methodsOptimal flip angles and repetition time parameters were determined from Monte Carlo simulations. BOAST was validated in the calf muscle of two volunteers at 3T and 7T. The myocardial CK forward rate constant was then measured in 10 volunteers at 7T in 82 min (after

resultsBOAST kfCK values were 0.281 ± 0.002 s

conclusionBOAST enables measurement of the CK rate constant in the human heart at 7T, with spatial localization in three dimensions to 5.6 mL voxels, using a 10-cm loop coil. Magn Reson Med 78:20-32, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Indexed as

AdultCreatine KinaseEnzyme ActivationFemaleHeartHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMetabolic Clearance RateMolecular ImagingMyocardiumProton Magnetic Resonance SpectroscopyReproducibility of ResultsSensitivity and SpecificityTissue DistributionCreatine Kinase31P magnetic resonance spectroscopy7T7 teslacardiaccreatine kinaseenergy metabolismhigh-energy phosphatephosphorussaturation transfer

Identifiers

PMID27579566
PMCPMC5484353
OpenAlexW2516554826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.