SynthesisOncotarget2017
Combined effect of body mass index and metabolic status on the risk of prevalent and incident chronic kidney disease: a systematic review and meta-analysis.
Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence of chronic kidney disease stages 3-5 in low- and middle-income countries in Asia: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Obesity as a predictive factor for chronic kidney disease in adults: systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- Baseline and Follow-Up Association between Adiposity and Renal Function: Data from the ILERVAS Cohort.Obesity facts · 2026Article
- Relationships Between Metabolic and Bariatric Surgery and Adverse Kidney Outcomes: An Analysis of a Retrospective Cohort.Obesity science & practice · 2025Article
- Association between metabolic health status and chronic kidney disease in the population of the northern region of Senegal: a cross-sectional study.BMC nephrology · 2025Article
- Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice.American journal of physiology. Renal physiology · 2025Article
- The interplay between excess weight and hyper-glycemia on NCDs in Italy: results from a cross-sectional study.Acta diabetologica · 2024Article
- Six months of physical inactivity is insufficient to cause chronic kidney disease in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024Article
- Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study.Lipids in health and disease · 2024Article
- Metabolic health status and renal disorders: a cross-sectional study.Scientific reports · 2023Article
- Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts.Nature communications · 2023Article
- Obesity and chronic kidney disease: A current review.Obesity science & practice · 2023Review
- Obesity Patterns, Metabolic Abnormality, and Diabetic Kidney Disease in Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Metabolic associated fatty liver disease is a risk factor for chronic kidney disease.Journal of diabetes investigation · 2022Article
- Effects of Body Weight Change on Development of Chronic Kidney Disease in Obese Metabolic Phenotypes.Nephron · 2022Article
- Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study.Frontiers in public health · 2022Observational
- Metabolic Health, Obesity, and Renal Function: 2013-2018 National Health and Nutrition Examination Surveys.Life (Basel, Switzerland) · 2021Article
- Combined Associations of Body Mass Index and Metabolic Health Status on Medical and Dental Care Days and Costs in Japanese Male Employees: A 4-Year Follow-Up Study.Journal of epidemiology · 2020Article
- Impact of metabolically healthy obesity on the risk of incident gastric cancer: a population-based cohort study.BMC endocrine disorders · 2020Article
- Metabolically Healthy Obesity and Risk of Incident Chronic Kidney Disease in a Korean Cohort Study.Iranian journal of public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe risk of chronic kidney disease (CKD) differs in the normal weight, overweight, and obese individuals owing to metabolic abnormality. We aimed to determine the combined effects of body mass index (BMI) and metabolic status on the risk of the prevalence and incidence of CKD.
methodsPubmed, Scopus, Web of science, and abstracts from recently relevant meetings prior to April 2016 were searched to identify eligible studies. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated using a random effects model.
resultsEight cross-sectional studies and four longitudinal follow-up studies with a total of 14787 and 166718 participants were separately included in present study. Compared with metabolically healthy normal weight individuals, metabolically healthy obese individuals showed increased risk for CKD, with RR of 1.235 (95%CI: 1.027 to 1.484), while metabolically health overweight individuals still presented in a healthy pattern, RR=1.094(95%CI: 0.774 to 1.547). In addition, metabolically abnormal groups had much higher risk for CKD, with RR of 1.572 (95%CI: 1.373 to 1.801), 1.652(95%CI: 1.139 to 2.397) and 1.898(95%CI: 1.505 to 2.395) across metabolically unhealthy normal weight, overweight and obese individuals respectively.
conclusionIndividuals with abnormal metabolic status are at a significantly elevated risk for CKD, regardless of BMI. For metabolically healthy individuals, CKD risk increases with the growth of BMI, and obese persons eventually have a higher risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.