ArticleNeural plasticity2016
Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Animal Models for Anorexia Nervosa-A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- Chronic activity-based anorexia triggers a glial response in the hippocampus independent of intestinal epithelial toll-like receptor 4.Journal of neuroinflammation · 2026Article
- The Influence of Omega-3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model.The International journal of eating disorders · 2026Article
- DSOK-0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity-Based Anorexia Model.The International journal of eating disorders · 2026Article
- Increased Serum Neurofilament Light Chain Concentration Associated With Microglial Morphology Changes in Chronically-Starved Mice.The International journal of eating disorders · 2025Article
- Chronic starvation induces microglial cell depletion in an activity-based anorexia model.Scientific reports · 2025Article
- Changes in Circadian Rhythm in Chronically-Starved Mice Are Associated With Glial Cell Density Reduction in the Suprachiasmatic Nucleus.The International journal of eating disorders · 2025Article
- Glial cell changes in the corpus callosum in chronically-starved mice.Journal of eating disorders · 2023Article
- Normalized Brain Tissue-Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports.Neurotrauma reports · 2022Article
- Glial cells in anorexia.Frontiers in cellular neuroscience · 2022Review
- The Role of Glial Cells in Regulating Feeding Behavior: Potential Relevance to Anorexia Nervosa.Journal of clinical medicine · 2021Review
- Thirty years after anorexia nervosa onset, serum neurofilament light chain protein concentration indicates neuronal injury.European child & adolescent psychiatry · 2021Article
- Long-Term Glucose Starvation Induces Inflammatory Responses and Phenotype Switch in Primary Cortical Rat Astrocytes.Journal of molecular neuroscience : MN · 2021Article
- Differential longitudinal changes of neuronal and glial damage markers in anorexia nervosa after partial weight restoration.Translational psychiatry · 2021Article
- Brain Volume Loss, Astrocyte Reduction, and Inflammation in Anorexia Nervosa.Advances in neurobiology · 2021Article
- Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction.The Journal of international medical research · 2019Article
- The reduction of astrocytes and brain volume loss in anorexia nervosa-the impact of starvation and refeeding in a rodent model.Translational psychiatry · 2019Article
- Extend, Pathomechanism and Clinical Consequences of Brain Volume Changes in Anorexia Nervosa.Current neuropharmacology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anorexia nervosa is an eating disorder observed primarily in young women. The neurobiology of the disorder is unknown but recently magnetic resonance imaging showed a volume reduction of the hippocampus in anorexic patients. Dehydration-induced anorexia (DIA) is a murine model that mimics core features of this disorder, including severe weight loss due to voluntary reduction in food intake. The energy supply to the brain is mediated by astrocytes, but whether their density is compromised by anorexia is unknown. Thus, the aim of this study was to estimate GFAP+ cell density in the main regions of the hippocampus (CA1, CA2, CA3, and dentate gyrus) in the DIA model. Our results showed that GFAP+ cell density was significantly reduced (~20%) in all regions of the hippocampus, except in CA1. Interestingly, DIA significantly reduced the GFAP+ cells/nuclei ratio in CA2 (-23%) and dentate gyrus (-48%). The reduction of GFAP+ cell density was in agreement with a lower expression of GFAP protein. Additionally, anorexia increased the expression of the intermediate filaments vimentin and nestin. Accordingly, anorexia increased the number of reactive astrocytes in CA2 and dentate gyrus more than twofold. We conclude that anorexia reduces the hippocampal GFAP+ cell density and increases vimentin and nestin expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.