ReviewBoneKEy reports2016
Effects of myokines on bone.
Review in BoneKEy reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 156 citations in OpenAlex.
- Body Composition Phenotypes and Their Metabolic Associations in Treatment-Naïve Patients With Newly Diagnosed Type 2 Diabetes: A DXA-Based Cluster Analysis.Endocrinology, diabetes & metabolism · 2026Article
- Biomarkers of Sarcopenia: Current Status and Future Perspectives.Aging medicine (Milton (N.S.W)) · 2026Review
- Mechanisms and precision interventions in sarcopenia and osteoarthritis comorbidity: A narrative review.Journal of orthopaedic translation · 2026Review
- Beyond bone density: toward an integrated bone- muscle-function framework for fragility fracture prevention.Frontiers in medicine · 2026Article
- Association between appendicular skeletal muscle index and bone turnover markers and bone mineral density in postmenopausal osteoporotic women.Archives of osteoporosis · 2025Article
- Evaluation of irisin levels in plasma, skeletal muscle, and brain tissues after voluntary or regular exercise in adolescent male rats exposed to chronic social isolation.Biologia futura · 2025Article
- Association between hand grip strength and bone mineral density in US adolescents aged 12-19 years: a cross-sectional study.European journal of pediatrics · 2025Article
- Correlations of serum myostatin and irisin with sarcopenia and osteoporosis in rheumatoid arthritis patients: a cross-sectional study.Scientific reports · 2025Article
- Bone and muscle crosstalk in ageing and disease.Nature reviews. Endocrinology · 2025Review
- Roles of Insulin-Like Growth Factor-1 in Muscle Wasting and Osteopenia in Mice with Hyponatremia.Calcified tissue international · 2025Article
- Impact of myosteatosis on prognosis in multiple myeloma patients: A subgroup analysis of 182 cases and development of a nomogram.Journal of bone oncology · 2025Article
- Skeletal Muscle as Endocrine Organ.Advances in experimental medicine and biology · 2025Review
- The role of bone-derived factors in bone and muscle communication.Frontiers in endocrinology · 2025Review
- Association between urine creatinine excretion and bone mineral density in chronic kidney disease: Results from the KNOW-CKD study.Journal of nephrology · 2025Article
- Androgen receptor and osteoglycin gene expression predicting prognosis of metastatic prostate cancer.Scientific reports · 2024Article
- High Serum Irisin Concentration Is Associated with More Disturbed Behavioural Eating Pattern in Adolescent Rhythmic Gymnasts.Children (Basel, Switzerland) · 2024Article
- Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Crosstalk between muscle and bone.Journal of bone and mineral metabolism · 2024Review
- Serum myokines as potential biomarkers of myostatin inhibition in sport doping: a preliminary study on their baseline levels in elite athletes.Biology of sport · 2024Article
- Serum biomarkers related to frailty predict negative outcomes in older adults with hip fracture.Journal of endocrinological investigation · 2024Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The links between muscle and bone have been recently examined because of the increasing number of patients with osteoporosis and sarcopenia. Myokines are skeletal muscle-derived humoral cytokines and growth factors, which exert physiological and pathological functions in various distant organs, including the regulation of glucose, energy and bone metabolism. Myostatin is a crucial myokine, the expression of which is mainly limited to muscle tissues. The inhibition of myostatin signaling increases bone remodeling, bone mass and muscle mass, and it may provide a target for the treatment of both sarcopenia and osteoporosis. As myostatin is involved in osteoclast formation and bone destruction in rheumatoid arthritis, myostatin may be a target myokine for the treatment of accelerated bone resorption and joint destruction in rheumatoid arthritis. Numerous other myokines, including transforming growth factor-β, follistatin, insulin-like growth factor-I, fibroblast growth factor-2, osteoglycin, FAM5C, irisin, interleukin (IL)-6, leukemia inhibitory factor, IL-7, IL-15, monocyte chemoattractant protein-1, ciliary neurotrophic factor, osteonectin and matrix metalloproteinase 2, also affect bone cells in various manners. However, the effects of myokines on bone metabolism are largely unknown. Further research is expected to clarify the interaction between muscle and bone, which may lead to greater diagnosis and the development of the treatment for muscle and bone disorders, such as osteoporosis and sarcopenia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.