ArticleDevelopment (Cambridge, England)2016
Identification, visualization and clonal analysis of intestinal stem cells in fish.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Cetobacterium somerae ZNN-1 promotes goblet cell differentiation through glutamine-mediated Notch signaling suppression.Journal of advanced research · 2026Article
- A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation.Disease models & mechanisms · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns.Aging cell · 2025Article
- Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine.Cell and tissue research · 2024Article
- Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics.PLoS biology · 2023Article
- Omics and imaging combinatorial approach reveals butyrate-induced inflammatory effects in the zebrafish gut.Animal microbiome · 2023Article
- The manipulation of cell suspensions from zebrafish intestinal mucosa contributes to understanding enteritis.Frontiers in immunology · 2023Article
- Cell clusters containing intestinal stem cells line, the zebrafish intestine intervillus pocket.iScience · 2022Article
- Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine.Mucosal immunology · 2022Article
- GPR15-C10ORF99 functional pairing initiates colonic Treg homing in amniotes.EMBO reports · 2022Article
- Telocytes: Active Players in the Rainbow Trout (Animals : an open access journal from MDPI · 2021Article
- Igf signaling couples retina growth with body growth by modulating progenitor cell division.Development (Cambridge, England) · 2021Article
- The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish.Biology open · 2021Article
- Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium.Nature reviews. Gastroenterology & hepatology · 2021Review
- The 3D Pattern of the Rainbow Trout (International journal of molecular sciences · 2020Article
- The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent.Development (Cambridge, England) · 2020Article
- celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.eLife · 2020Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, a stochastic model of symmetrical stem cell division followed by neutral drift has been proposed for intestinal stem cells (ISCs), which has been suggested to represent the predominant mode of stem cell progression in mammals. In contrast, stem cells in the retina of teleost fish show an asymmetric division mode. To address whether the mode of stem cell division follows phylogenetic or ontogenetic routes, we analysed the entire gastrointestinal tract of the teleost medaka (Oryzias latipes). X-ray microcomputed tomography shows a correlation of 3D topography with the functional domains. Analysis of ISCs in proliferation assays and via genetically encoded lineage tracing highlights a stem cell niche in the furrow between the long intestinal folds that is functionally equivalent to mammalian intestinal crypts. Stem cells in this compartment are characterized by the expression of homologs of mammalian ISC markers - sox9, axin2 and lgr5 - emphasizing the evolutionary conservation of the Wnt pathway components in the stem cell niche of the intestine. The stochastic, sparse initial labelling of ISCs ultimately resulted in extended labelled or unlabelled domains originating from single stem cells in the furrow niche, contributing to both homeostasis and growth. Thus, different modes of stem cell division co-evolved within one organism, and in the absence of physical isolation in crypts, ISCs contribute to homeostatic growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.