ArticleMolecular biology and evolution2016
A High-Coverage Yersinia pestis Genome from a Sixth-Century Justinianic Plague Victim.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 132 citations in OpenAlex.
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- Analysis of Genomic DNA from Medieval Plague Victims Suggests Long-Term Effect of Yersinia pestis on Human Immunity Genes.Molecular biology and evolution · 2021Article
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- A genomic and historical synthesis of plague in 18th century Eurasia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Recovery, Interpretation and Use of Ancient Pathogen Genomes.Current biology : CB · 2020Review
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Authors and funding
13 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The Justinianic Plague, which started in the sixth century and lasted to the mid eighth century, is thought to be the first of three historically documented plague pandemics causing massive casualties. Historical accounts and molecular data suggest the bacterium Yersinia pestis as its etiological agent. Here we present a new high-coverage (17.9-fold) Y. pestis genome obtained from a sixth-century skeleton recovered from a southern German burial site close to Munich. The reconstructed genome enabled the detection of 30 unique substitutions as well as structural differences that have not been previously described. We report indels affecting a lacl family transcription regulator gene as well as nonsynonymous substitutions in the nrdE, fadJ, and pcp genes, that have been suggested as plague virulence determinants or have been shown to be upregulated in different models of plague infection. In addition, we identify 19 false positive substitutions in a previously published lower-coverage Y. pestis genome from another archaeological site of the same time period and geographical region that is otherwise genetically identical to the high-coverage genome sequence reported here, suggesting low-genetic diversity of the plague during the sixth century in rural southern Germany.
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