ArticleScientific reports2016
Development of functionalized multi-walled carbon-nanotube-based alginate hydrogels for enabling biomimetic technologies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 124 citations in OpenAlex.
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- Carbon Nanotube Hydrogel Electrodes for High-Fidelity Intra-Aural EEG in Wearable Neurotechnology.Sensors (Basel, Switzerland) · 2026Article
- Conductive Fibers of Chitosan/DNA Interfacial Polyelectrolyte Complexation Incorporating Carbon Nanotubes.ACS applied materials & interfaces · 2026Article
- Smart alginate inks for tissue engineering applications.Materials today. Bio · 2023Review
- Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system.RSC advances · 2023Article
- Sodium Alginate/β-Cyclodextrin Reinforced Carbon Nanotubes Hydrogel as Alternative Adsorbent for Nickel(II) Metal Ion Removal.Polymers · 2022Article
- Engineering approaches for cardiac organoid formation and their characterization.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Alginate: Enhancement Strategies for Advanced Applications.International journal of molecular sciences · 2022Review
- Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma.Materials (Basel, Switzerland) · 2022Article
- Green Hydrogels Composed of Sodium Mannuronate/Guluronate, Gelatin and Biointeractive Calcium Silicates/Dicalcium Phosphate Dihydrate Designed for Oral Bone Defects Regeneration.Nanomaterials (Basel, Switzerland) · 2021Article
- Tuning Physicochemical Properties of a Macroporous Polysaccharide-Based Scaffold for 3D Neuronal Culture.International journal of molecular sciences · 2021Article
- A Model for Studying the Biomechanical Effects of Varying Ratios of Collagen Types I and III on Cardiomyocytes.Cardiovascular engineering and technology · 2021Article
- Antidegradation Property of Alginate Materials by Riveting Functionalized Carbon Nanotubes on the Sugar Chain.ACS omega · 2021Article
- Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration.Materials (Basel, Switzerland) · 2020Review
- Carbon Nanotubes Interference with Luminescence-Based Assays.Materials (Basel, Switzerland) · 2020Article
- Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds.Materials (Basel, Switzerland) · 2020Review
- Hydrogel scaffolds with elasticity-mimicking embryonic substrates promote cardiac cellular network formation.Progress in biomaterials · 2020Article
- Flexible Electrode Based on MWCNT Embedded in a Cross-Linked Acrylamide/Alginate Blend: Conductivity vs. Stretching.Polymers · 2020Article
- Current Status of Alginate in Drug Delivery.Advances in pharmacological and pharmaceutical sciences · 2020Review
- Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.International journal of nanomedicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alginate is a hydrogel commonly used for cell culture by ionically crosslinking in the presence of divalent Ca(2+) ions. However these alginate gels are mechanically unstable, not permitting their use as scaffolds to engineer robust biological bone, breast, cardiac or tumor tissues. This issue can be addressed via encapsulation of multi-walled carbon nanotubes (MWCNT) serving as a reinforcing phase while being dispersed in a continuous phase of alginate. We hypothesized that adding functionalized MWCNT to alginate, would yield composite gels with distinctively different mechanical, physical and biological characteristics in comparison to alginate alone. Resultant MWCNT-alginate gels were porous, and showed significantly less degradation after 14 days compared to alginate alone. In vitro cell-studies showed enhanced HeLa cell adhesion and proliferation on the MWCNT-alginate compared to alginate. The extent of cell proliferation was greater when cultured atop 1 and 3 mg/ml MWCNT-alginate; although all MWCNT-alginates lead to enhanced cell cluster formation compared to alginate alone. Among all the MWCNT-alginates, the 1 mg/ml gels showed significantly greater stiffness compared to all other cases. These results provide an important basis for the development of the MWCNT-alginates as novel substrates for cell culture applications, cell therapy and tissue engineering.
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