ArticleScientific reports2016
Overweight status is associated with extensive signs of microvascular dysfunction and cardiovascular risk.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Effect of Bariatric Surgery on Improvement of Retinal Microvasculature in Patients With Obesity: A Systematic Review and Meta-Analysis.Clinical obesity · 2026Pooled it
- Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adults.The Journal of nutrition · 2021Trial
- Retinal Microvascular Calibres and Body Fat Indices in Young Adults.International journal of environmental research and public health · 2026Article
- Relationship Between Retinal Vascular Measurements and Anthropometric Indices in Patients Diagnosed with Persistent COVID-19.Journal of clinical medicine · 2025Article
- The Effect of Bariatric Surgery on Microvascular Structure and Function, Peripheral Pressure Waveform and General Cardiovascular Risk: A Longitudinal Study.Journal of clinical medicine · 2023Article
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
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- Role of von Willebrand factor in venous thromboembolic disease.JVS-vascular science · 2022Review
- Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk.Scientific reports · 2021Article
- Inflammatory Mechanisms Contributing to Endothelial Dysfunction.Biomedicines · 2021Review
- European Society of Cardiology/European Society of Hypertension versus the American College of Cardiology/American Heart Association guidelines on the cut-off values for early hypertension: a microvascular perspective.Scientific reports · 2021Article
- Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.Cardiovascular research · 2021Review
- Quantification of Retinal Vessel Myogenic Constriction in Response to Blood Pressure Peaks: Implications for Flicker Light-Induced Dilatation.Frontiers in physiology · 2021Article
- Predictors of recurrent angina in patients with no need for secondary revascularization.World journal of emergency medicine · 2021Article
- In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network.Microcirculation (New York, N.Y. : 1994) · 2020Article
- The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children.BMC endocrine disorders · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this present study was to investigate if overweight individuals exhibit signs of vascular dysfunction associated with a high risk for cardiovascular disease (CVD). One hundred lean and 100 overweight participants were recruited for the present study. Retinal microvascular function was assessed using the Dynamic Retinal Vessel Analyser (DVA), and systemic macrovascular function by means of flow-mediated dilation (FMD). Investigations also included body composition, carotid intimal-media thickness (c-IMT), ambulatory blood pressure monitoring (BP), fasting plasma glucose, triglycerides (TG), cholesterol levels (HDL-C and LDL-C), and plasma von Willebrand factor (vWF). Overweight individuals presented with higher right and left c-IMT (p = 0.005 and p = 0.002, respectively), average 24-h BP values (all p < 0.001), plasma glucose (p = 0.008), TG (p = 0.003), TG: HDL-C ratio (p = 0.010), and vWF levels (p = 0.004). Moreover, overweight individuals showed lower retinal arterial microvascular dilation (p = 0.039) and baseline-corrected flicker (bFR) responses (p = 0.022), as well as, prolonged dilation reaction time (RT, p = 0.047). These observations emphasise the importance of vascular screening and consideration of preventive interventions to decrease vascular risk in all individuals with adiposity above normal range.
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Registered trials
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