ArticlePlant physiology2016
Opposing Control by Transcription Factors MYB61 and MYB3 Increases Freezing Tolerance by Relieving C-Repeat Binding Factor Suppression.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- MdRAD5B regulates the chromatin accessibility of MdMYB14 under cold by associating with a transcription factor MdLSD1.Science China. Life sciences · 2026Article
- Machine learning-guided leaf margin classification and discovery that BcPHB promoter selection rewires a BcPHB-BcLMI1 module to shape leaf margins in Brassica campestris.Molecular horticulture · 2026Article
- MYB transcription factors in plant cold stress adaptation: integrating phylogeny, signaling networks, and metabolic regulation.Physiology and molecular biology of plants : an international journal of functional plant biology · 2026Review
- PuCBL9-PuCIPK11 Modulates Stomatal Microfilament Reorganisation in a Phosphorylation-Dependent Manner to Enhance Drought Tolerance in Poplar.Plant, cell & environment · 2026Article
- PaMYBS3 balances cold tolerance and growth inhibition as a cold acclimation strategy in Plumbago auriculata L.BMC plant biology · 2026Article
- Deciphering the ceRNA Network in Alfalfa: Insights into Cold Stress Tolerance Mechanisms.Biomolecules · 2026Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
- The S-acylation cycle of transcription factor MtNAC80 influences cold stress responses in Medicago truncatula.The Plant cell · 2024Article
- Molecular switches in plant stress adaptation.Molecular biology reports · 2023Review
- Calcium-dependent protein kinases CPK21 and CPK23 phosphorylate and activate the iron-regulated transporter IRT1 to regulate iron deficiency in Arabidopsis.Science China. Life sciences · 2023Article
- A calmodulin-like protein (CML10) interacts with cytosolic enzymes GSTU8 and FBA6 to regulate cold tolerance.Plant physiology · 2022Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2022Article
- Identification of candidate MYB transcription factors that influenceFrontiers in plant science · 2022Article
- Comparative transcriptome analysis unveiling reactive oxygen species scavenging system ofFrontiers in plant science · 2022Article
- Tolerant mechanism of model legume plantFrontiers in plant science · 2022Review
- Evolution and functional diversification of R2R3-MYB transcription factors in plants.Horticulture research · 2022Article
- Differences in lipid homeostasis and membrane lipid unsaturation confer differential tolerance to low temperatures in two Cycas species.BMC plant biology · 2021Article
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- Identification of tissue-specific and cold-responsive lncRNAs in Medicago truncatula by high-throughput RNA sequencing.BMC plant biology · 2020Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold acclimation is an important process by which plants respond to low temperature and enhance their winter hardiness. C-REPEAT BINDING FACTOR1 (CBF1), CBF2, and CBF3 genes were shown previously to participate in cold acclimation in Medicago truncatula In addition, MtCBF4 is transcriptionally induced by salt, drought, and cold stresses. We show here that MtCBF4, shown previously to enhance drought and salt tolerance, also positively regulates cold acclimation and freezing tolerance. To identify molecular factors acting upstream and downstream of the MtCBF4 transcription factor (TF) in cold responses, we first identified genes that are differentially regulated upon MtCBF4 overexpression using RNAseq Digital Gene Expression Profiling. Among these, we showed that MtCBF4 directly activates the transcription of the COLD ACCLIMATION SPECIFIC15 (MtCAS15) gene. To gain insights into how MtCBF4 is transcriptionally regulated in response to cold, an R2R3-MYB TF, MtMYB3, was identified based on a yeast one-hybrid screen as binding directly to MYB cis-elements in the MtCBF4 promoter, leading to the inhibition of MtCBF4 expression. In addition, another MYB TF, MtMYB61, identified as an interactor of MtMYB3, can relieve the inhibitory effect of MtMYB3 on MtCBF4 transcription. This study, therefore, supports a model describing how MtCBF4 is regulated by antagonistic MtMYB3/MtMYB61 TFs, leading to the up-regulation of downstream targets such as MtCAS15 acting in cold acclimation in M. truncatula.
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