Evidence map›Paper›PMID 27578547›Full record

ArticleScientific reports2016

Influence of HLA on human partnership and sexual satisfaction.

J Kromer, T Hummel, D Pietrowski, A S Giani, J Sauter, G Ehninger, A H Schmidt, I Croy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Pooled it
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  10. Body odours as a chemosignal in the mother-child relationship: new insights based on an human leucocyte antigen-genotyped family cohort.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Article
  11. Multiplicative fitness, rapid haplotype discovery, and fitness decay explain evolution of human MHC.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  12. Article
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  15. Reproducing with DNA.Nature biotechnology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

J KromerSmell &Taste Clinic, Department of Otorhinolaryngology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany.
T HummelSmell &Taste Clinic, Department of Otorhinolaryngology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany.
D PietrowskiSmell &Taste Clinic, Department of Otorhinolaryngology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany.
A S GianiDKMS German Bone Marrow Donor Center, Kressbach 1, 72072 Tübingen, Germany.
J SauterDKMS German Bone Marrow Donor Center, Kressbach 1, 72072 Tübingen, Germany.
G EhningerDepartment of Internal Medicine, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany.
A H SchmidtDKMS German Bone Marrow Donor Center, Kressbach 1, 72072 Tübingen, Germany.
I CroySmell &Taste Clinic, Department of Otorhinolaryngology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307 Dresden, Germany.
TU Dresden · DEGerman National Bone Marrow Donor Registry · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The major histocompatibility complex (MHC, called HLA in humans) is an important genetic component of the immune system. Fish, birds and mammals prefer mates with different genetic MHC code compared to their own, which they determine using olfactory cues. This preference increases the chances of high MHC variety in the offspring, leading to enhanced resilience against a variety of pathogens. Humans are also able to discriminate HLA related olfactory stimuli, however, it is debated whether this mechanism is of behavioural relevance. We show on a large sample (N = 508), with high-resolution typing of HLA class I/II, that HLA dissimilarity correlates with partnership, sexuality and enhances the desire to procreate. We conclude that HLA mediates mate behaviour in humans.

Indexed as

AdolescentAdultFemaleGene ExpressionHistocompatibility TestingHLA AntigensHumansMaleMiddle AgedOlfactory PerceptionReproductive BehaviorSequence Analysis, DNASexual BehaviorSmellHLA Antigens

Identifiers

PMID27578547
PMCPMC5006172
OpenAlexW2508477217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.