Evidence map›Paper›PMID 27578504›Full record

ArticleAnnals of laboratory medicine2016

Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population: MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations.

Misuk Ji, Yoon Hee Lee, Mina Hur, Hyesun Kim, Han Ik Cho, Hyun Suk Yang, Silvia Navarin, Salvatore Di Somma, GREAT Network

Abstract readComparative Study
In one paragraph

Article in Annals of laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Urinary peptide analysis to predict the response to blood pressure medication.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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  7. The ideal marker for measuring GFR: what are we looking for?Acta bio-medica : Atenei Parmensis · 2020
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Misuk JiDepartment of Laboratory Medicine, Veterans Health Service Medical Center, Seoul, Korea.
Yoon Hee LeeKorea Association of Health Promotion, Seoul, Korea.
Mina HurDepartment of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea. dearmina@hanmail.net.
Hyesun KimKorea Association of Health Promotion, Seoul, Korea.
Han Ik ChoKorea Association of Health Promotion, Seoul, Korea.
Hyun Suk YangDepartment of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea.
Silvia NavarinDepartment of Medical Sciences and Translational Medicine, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy.
Salvatore Di SommaDepartment of Medical Sciences and Translational Medicine, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy.
GREAT Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstimated glomerular filtration rate (eGFR) is a widely used index of kidney function. Recently, new formulas such as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations or the Lund-Malmö equation were introduced for assessing eGFR. We compared them with the Modification of Diet in Renal Disease (MDRD) Study equation in the Korean adult population.

methodsThe study population comprised 1,482 individuals (median age 51 [42-59] yr, 48.9% males) who received annual physical check-ups during the year 2014. Serum creatinine (Cr) and cystatin C (CysC) were measured. We conducted a retrospective analysis using five GFR estimating equations (MDRD Study, revised Lund-Malmö, and Cr and/or CysC-based CKD-EPI equations). Reduced GFR was defined as eGFR <60 mL/min/1.73 m².

resultsFor the GFR category distribution, large discrepancies were observed depending on the equation used; category G1 (≥90 mL/min/1.73 m²) ranged from 7.4-81.8%. Compared with the MDRD Study equation, the other four equations overestimated GFR, and CysC-based equations showed a greater difference (-31.3 for CKD-EPI(CysC) and -20.5 for CKD-EPI(Cr-CysC)). CysC-based equations decreased the prevalence of reduced GFR by one third (9.4% in the MDRD Study and 2.4% in CKD-EPI(CysC)).

conclusionsOur data shows that there are remarkable differences in eGFR assessment in the Korean population depending on the equation used, especially in normal or mildly decreased categories. Further prospective studies are necessary in various clinical settings.

Indexed as

AlgorithmsAdultAgedCreatinineCystatin CFemaleGlomerular Filtration RateHumansMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesCreatinineCystatin CCKD-EPI equationEstimated glomerular filtration rateMDRD Study equationRevised Lund-Malmö equation

Identifiers

PMID27578504
PMCPMC5011104

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