ArticleInternational journal of cancer2016
Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- PIWI family proteins as prognostic markers in cancer: a systematic review and meta-analysis.Cellular and molecular life sciences : CMLS · 2020Pooled it
- piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson's Disease.International journal of molecular sciences · 2021Review
- The biogenesis and biological function of PIWI-interacting RNA in cancer.Journal of hematology & oncology · 2021Review
- Computational Methods and Online Resources for Identification of piRNA-Related Molecules.Interdisciplinary sciences, computational life sciences · 2021Review
- piRNAs in Gastric Cancer: A New Approach Towards Translational Research.International journal of molecular sciences · 2020Review
- Site-Specific Expression Pattern of PIWI-Interacting RNA in Skin and Oral Mucosal Wound Healing.International journal of molecular sciences · 2020Article
- Single nucleotide polymorphisms in piRNA-pathway genes: an insight into genetic determinants of human diseases.Molecular genetics and genomics : MGG · 2020Review
- piRNAs Regulated by Mitochondria Variation Linked With Reproduction and Aging inFrontiers in genetics · 2020Article
- Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.Molecular cancer · 2019Article
- Overexpression of mRNA-decapping enzyme 1a affects survival rate in colorectal carcinoma.Oncology letters · 2018Article
- Multiple Linear Regression Analysis of lncRNA-Disease Association Prediction Based on Clinical Prognosis Data.BioMed research international · 2018Article
- Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.Molecular carcinogenesis · 2018Article
- Multiple similarly effective solutions exist for biomedical feature selection and classification problems.Scientific reports · 2017Article
- Genetic variants of cell cycle pathway genes predict disease-free survival of hepatocellular carcinoma.Cancer medicine · 2017Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development. In this study, we comprehensively analyzed prognostic roles of 3,116 common SNPs in PIWI-piRNA pathway genes in melanoma disease-specific survival. A published genome-wide association study (GWAS) by The University of Texas M.D. Anderson Cancer Center was used to identify associated SNPs, which were later validated by another GWAS from the Harvard Nurses' Health Study and Health Professionals Follow-up Study. After multiple testing correction, we found that there were 27 common SNPs in two genes (PIWIL4 and DCP1A) with false discovery rate < 0.2 in the discovery dataset. Three tagSNPs (i.e., rs7933369 and rs508485 in PIWIL4; rs11551405 in DCP1A) were replicated. The rs11551405 A allele, located at the 3' UTR microRNA binding site of DCP1A, was associated with an increased risk of melanoma disease-specific death in both discovery dataset [adjusted Hazards ratio (HR) = 1.66, 95% confidence interval (CI) = 1.21-2.27, p =1.50 × 10
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Registered trials
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