Evidence map›Paper›PMID 27578312›Full record

ArticleChemMedChem2016

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

Yang Wang, Janish Desai, Yonghui Zhang, Satish R Malwal, Christopher J Shin, Xinxin Feng, Hong Sun, Guizhi Liu, Rey-Ting Guo, Eric Oldfield

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yang WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Janish DesaiCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, IL, 61801, USA.ORCID 0000-0001-5487-1264
Yonghui ZhangDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Satish R MalwalDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Christopher J ShinDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Xinxin FengDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Hong SunIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Guizhi LiuIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Rey-Ting GuoIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Eric OldfieldDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA. eo@chad.scs.uiuc.edu.
University of Illinois Urbana-Champaign · USChinese Academy of Sciences · CN

Funding

Structure, Function and Inhibition of [4Fe-4S] ProteinsR01GM065307 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI OLDFIELD, ERIC · 2002 to 2017
$5.4M
Next generation bisphosphonates for chemo- and immuno-therapyR01CA158191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI OLDFIELD, ERIC · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA158191NIGMS NIH HHS R01 GM065307
6 · The paper itself

Abstract

We synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of Staphylococcus aureus and Bacillus subtilis. One of the most active compounds, 5-fluoro-2-(3-(octyloxy)benzamido)benzoic acid (7, ED

Indexed as

Alkyl and Aryl TransferasesAnti-Bacterial AgentsBacillus subtilisBenzoatesCell WallDose-Response Relationship, DrugEnzyme InhibitorsMicrobial Sensitivity TestsMolecular StructureOrganophosphorus CompoundsPhosphoric Monoester HydrolasesStaphylococcus aureusStructure-Activity RelationshipAlkyl and Aryl TransferasesAnti-Bacterial AgentsBenzoatesEnzyme InhibitorsOrganophosphorus Compoundsphenylphosphonic acidPhosphoric Monoester Hydrolasesundecaprenyl pyrophosphate synthetasebenzoic acidscell-wall biosynthesisdrug discoverymembrane proteinsStaphylococcus aureus

Identifiers

PMID27578312
PMCPMC5155509
OpenAlexW2509768883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.