ArticleScientific reports2016
Bacillus as a potential diagnostic marker for yellow tongue coating.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Perspectives on tongue coating: etiology, clinical management, and associated diseases - a narrative review.The Saudi dental journal · 2025Review
- Diagnosis of non-puerperal mastitis based on "whole tongue" features: non-invasive biomarker mining and diagnostic model construction.Frontiers in cellular and infection microbiology · 2025Article
- Potential Metabolic Markers in the Tongue Coating of Chronic Gastritis Patients for Distinguishing Between Cold Dampness Pattern and Damp Heat Pattern in Traditional Chinese Medicine Diagnosis.Journal of inflammation research · 2025Article
- Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients.Journal of oral microbiology · 2025Article
- Tongue feature dataset construction and real-time detection.PloS one · 2024Article
- Microbial community structure of different tongue fur types in patients with chronic gastritis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Development of a tongue image-based machine learning tool for the diagnosis of gastric cancer: a prospective multicentre clinical cohort study.EClinicalMedicine · 2023Article
- Study on tongue coating microbes of bitter taste, sticky and greasy taste in chronic atrophic gastritis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Microbiological characteristics of different tongue coatings in adults.BMC microbiology · 2022Article
- Species composition and overall diversity are significantly correlated between the tongue coating and gastric fluid microbiomes in gastritis patients.BMC medical genomics · 2022Article
- Microbial Characteristics of Common Tongue Coatings in Patients with Precancerous Lesions of the Upper Gastrointestinal Tract.Journal of healthcare engineering · 2022Article
- Oral-Gut Microbiome Analysis in Patients With Metabolic-Associated Fatty Liver Disease Having Different Tongue Image Feature.Frontiers in cellular and infection microbiology · 2022Article
- Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis.Chinese journal of integrative medicine · 2022Article
- The Herbal Formula CWBSD Improves Sleep Quality Dependent on Oral Microbial Type and Tongue Diagnostic Features in Insomnia.Journal of personalized medicine · 2021Article
- Microbial characteristics across different tongue coating types in a healthy population.Journal of oral microbiology · 2021Article
- Rewiring of Microbiota Networks in Erosive Inflammation of the Stomach and Small Bowel.Frontiers in bioengineering and biotechnology · 2020Article
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- Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis.Journal of pharmaceutical and biomedical analysis · 2019Article
- Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade.Protein & cell · 2019Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
Observation of tongue coating, a foundation for clinical diagnosis and treatment in traditional Chinese medicine (TCM), is a major indicator of the occurrence, development, and prognosis of disease. The biological basis of tongue diagnosis and relationship between the types and microorganisms of tongue coating remain elusive. Thirteen chronic erosive gastritis (CEG) patients with typical yellow tongue coating (YTC) and ten healthy volunteers with thin white tongue coating (WTC) were included in this study. Patients were provided a 2-course targeted treatment of a herbal medicine Ban Xia Xie Xin decoction, traditionally prescribed for CEG patients with YTC, to evaluate the relationship between tongue coating microbiota and diagnosis of CEG with typical YTC. The tongue coating segregation structure was determined using Illumina Miseq sequencing of the V4-V5 region of the 16S ribosomal RNA gene. Bacillus was significantly observed only in CEG patients with YTC, but not in patients who received the decoction. YTC (n = 22) and WTC (n = 29) samples were collected for bacterial culturing to illustrate the relationship between Bacillus and YTC. The Bacillus positivity rate of YTC samples was 72.7%; Bacillus was not observed in WTC samples. In conclusion, Bacillus was strongly associated with YTC.
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