ArticleDevelopment (Cambridge, England)2016
The migrations of Drosophila muscle founders and primordial germ cells are interdependent.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- Review
- Two sequential gene expression programs bridged by cell division support long-distance collective cell migration.Development (Cambridge, England) · 2024Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- BMP-gated cell-cycle progression drives anoikis during mesenchymal collective migration.Developmental cell · 2022Article
- Diverse roles of phosphatidate phosphatases in insect development and metabolism.Insect biochemistry and molecular biology · 2021Review
- Collective Migrations ofGenetics · 2020Review
- Cell interactions in collective cell migration.Development (Cambridge, England) · 2019Review
- Migrating cells control morphogenesis of substratum serving as track to promote directional movement of the collective.Development (Cambridge, England) · 2019Article
- Heterogeneity of primordial germ cells.Current topics in developmental biology · 2019Review
- Comparative analysis of gene expression profiles for several migrating cell types identifies cell migration regulators.Mechanisms of development · 2017Article
- A pilgrim's progress: Seeking meaning in primordial germ cell migration.Stem cell research · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Caudal visceral mesoderm (CVM) cells migrate from posterior to anterior of the Drosophila embryo as two bilateral streams of cells to support the specification of longitudinal muscles along the midgut. To accomplish this long-distance migration, CVM cells receive input from their environment, but little is known about how this collective cell migration is regulated. In a screen we found that wunen mutants exhibit CVM cell migration defects. Wunens are lipid phosphate phosphatases known to regulate the directional migration of primordial germ cells (PGCs). PGC and CVM cell types interact while PGCs are en route to the somatic gonadal mesoderm, and previous studies have shown that CVM impacts PGC migration. In turn, we found here that CVM cells exhibit an affinity for PGCs, localizing to the position of PGCs whether mislocalized or trapped in the endoderm. In the absence of PGCs, CVM cells exhibit subtle changes, including more cohesive movement of the migrating collective, and an increased number of longitudinal muscles is found at anterior sections of the larval midgut. These data demonstrate that PGC and CVM cell migrations are interdependent and suggest that distinct migrating cell types can coordinately influence each other to promote effective cell migration during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.