← Statins × glycemic control

Observational studyJournal of clinical lipidology

Statin treatment is associated with insulin sensitivity decrease in type 1 diabetes mellitus: A prospective, observational 56-month follow-up study.

Lea Duvnjak et al.PubMed ↗Publisher ↗

  • Statin uselooks bad hereHigher insulin sensitivity.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Statin use went with higher insulin sensitivity

+36%+31% to +43%

statin use vs no statin use, in patients with type 1 diabetes mellitus (T1DM)

Bigger than 3 in 10 for glycemic control

As reported

HR 1.36, 95% CI 1.31–1.43 · the paper's word: decrease in insulin sensitivity

Who was studied, and how

345people with type 1 diabetes, in this paper

Already taking statin use, or nottheir own situation, not assigned

on statin use
not on statin use

Statin use went with higher insulin sensitivity+36%

correlation, not a test

the abstract, start to end

… to statin use was 36.7% (hazard ratio 1.36; 95% confidence interval …

← favours treatmentfavours comparator →
could be chance
Decrease in insulin sensitivitystatin use vs no statin use, in patients with type 1 diabetes mellitus (T1DM)
HR 1.361.31–1.43
StatinsGlycemic control
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6 papers cite it

2017
2018
2019
2020
2021
2022
2023
2024
2025
pooled itcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27578133