ArticleJournal of clinical lipidology
Predictors of first-year statin medication discontinuation: A cohort study.
Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of statin intolerance: a meta-analysis.European heart journal · 2022 · on this mapPooled it
- The Statin Paradox: Drivers and Consequences of Therapy Discontinuation.Metabolites · 2026Review
- Determinants of adherence to obesity medication: A narrative review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Lipid management strategies for diabetic patients align with an evidence-based guideline.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Statin treatment for primary and secondary prevention in elderly patients-a cross-sectional study in Stockholm, Sweden.European journal of clinical pharmacology · 2024Article
- Abandonment of prescriptions in medically underserved areas: Primary medication non-adherence in community pharmacies in the delta region of the United States.Exploratory research in clinical and social pharmacy · 2024Article
- Inclisiran: A Review in Hypercholesterolemia.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Review
- Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases.Nature medicine · 2023Article
- Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men.British journal of clinical pharmacology · 2022Article
- A multistate transition model for statin-induced myopathy and statin discontinuation.CPT: pharmacometrics & systems pharmacology · 2021Article
- Optimal Medical Therapy Prescription in Patients with Acute Coronary Syndrome in the Netherlands: A Multicenter Pilot Registry.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Article
- Lifetime risk assessment in cholesterol management among hypertensive patients: observational cross-sectional study based on electronic health record data.BMC family practice · 2020Observational
- Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study.Scientific reports · 2019Article
- Predictors of first-year nonadherence and discontinuation of statins among older adults: a retrospective cohort study.British journal of clinical pharmacology · 2019Article
- Prevalence of statin use among high-risk patients in urban and rural Vellore, Tamil Nadu: A population-based cross-sectional study.Indian journal of pharmacologyArticle
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5 authors.
Funding
Abstract
backgroundThe discontinuation of statin medication is associated with an increased risk of cardiovascular and cerebrovascular events and, among high-risk patients, all-cause mortality, but the reasons for discontinuation among statin initiators in clinical practice are poorly understood.
objectiveTo examine factors predicting the early discontinuation of statin therapy.
methodsIn this prospective cohort study, participants with baseline measurements before the initiation of statin treatment were linked to national registers and followed for the discontinuation of statins during the first year of treatment (no filled prescriptions after statin initiation within the subsequent 12 months).
resultsOf all the 9285 statin initiators, 12% (n = 1142) were discontinuers. Obesity, overweight, vascular comorbidities, and older age were independently associated with a reduced risk of discontinuation [odds ratios (OR) = 0.82 (95% confidence interval [CI], 0.69-0.99), 0.85 (95% CI, 0.73-0.98), 0.80 (95% CI, 0.68-0.93), and 0.82 (95% CI, 0.68-0.99), respectively]. In contrast, high-patient cost-sharing was associated with an increased odds (OR = 1.29; 95% CI, 1.03-1.62) for discontinuation. The only significant difference between the sexes (P = .002) was observed among the participants with risky alcohol use, which was associated with a decreased odds for discontinuation among the men (OR = 0.69; 95% CI, 0.49-0.98) and an increased odds among the women (OR = 1.28; 95% CI, 1.02-1.62).
conclusionsThe discontinuation of statin therapy during the first year after initiation is common. Lowering out-of-pocket expenditures and focusing on low-risk patient groups and women with risky alcohol use could help maintain the continuation of medication.
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