ArticleEuropean radiology2017
Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
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Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diffusion-weighted imaging of the breast-a consensus and mission statement from the EUSOBI International Breast Diffusion-Weighted Imaging working group.European radiology · 2020Guideline
- Diagnostic performance of breast tumor tissue selection in diffusion weighted imaging: A systematic review and meta-analysis.PloS one · 2020Pooled it
- [Contrast agent-free breast MRI : Advantages and potential disadvantages].Der Radiologe · 2019Pooled it
- Comparison of different ROI analysis methods for liver lesion characterization with simplified intravoxel incoherent motion (IVIM).Scientific reports · 2021Trial
- A multiparametric [European journal of nuclear medicine and molecular imaging · 2019Trial
- Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702).Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Trial
- Additional diagnostic value of lesion visibility on diffusion-weighted imaging for differentiating BI-RADS category 4 MRI-detected breast lesions.Japanese journal of radiology · 2026Article
- Automated Apparent Diffusion Coefficient Measurement of Breast Tumors in Diffusion-weighted MRI for Early Neoadjuvant Chemotherapy Response Assessment.Radiology. Imaging cancer · 2026Article
- Multicenter development and external validation of clinical-radiomics models to predict surgically confirmed upstaging in biopsy-proven DCIS using DCE-MRI.Journal of applied clinical medical physics · 2026Article
- Hybrid [Bioengineering (Basel, Switzerland) · 2026Article
- Establishing an Evidence-based Modern Breast MRI Program.Journal of breast imaging · 2026Review
- Tumor apparent diffusion coefficient as a predictive marker for PD-1 inhibitor outcome in advanced cervical cancer: a retrospective study.Frontiers in oncology · 2026Article
- Segmental Non-Mass Enhancement Features in Breast Magnetic Resonance Imaging: A Multicenter Retrospective Study of Histopathologic Correlations.Diagnostics (Basel, Switzerland) · 2025Article
- Reducing breast biopsy at MRI: comparison of minimum ADC cutoff and mean ADC cutoff identified by the ECOG-ACRIN A6702 multicenter trial.BMC cancer · 2025Article
- Discrimination Between Benign and Malignant Lesions With Restriction Spectrum Imaging MRI in an Enriched Breast Cancer Screening Cohort.Journal of magnetic resonance imaging : JMRI · 2025Article
- Magnetic resonance imaging features and diagnostic value analysis of non-mass enhancement lesions of the breast.Quantitative imaging in medicine and surgery · 2025Article
- Quantitative MR Imaging of the Breast.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Association between programmed cell death ligand-1 expression in patients with cervical cancer and apparent diffusion coefficient values: a promising tool for patient´s immunotherapy selection.European radiology · 2024Article
- Simultaneous multislice echo-planar diffusion-weighted imaging (DWI) in patients with focal liver lesions: a comparative study with conventional DWI.Quantitative imaging in medicine and surgery · 2024Article
- Non-contrast Breast MR Imaging.Radiologic clinics of North America · 2024Review
7 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
objectivesTo investigate the influence of region-of-interest (ROI) placement and different apparent diffusion coefficient (ADC) parameters on ADC values, diagnostic performance, reproducibility and measurement time in breast tumours.
methodsIn this IRB-approved, retrospective study, 149 histopathologically proven breast tumours (109 malignant, 40 benign) in 147 women (mean age 53.2) were investigated. Three radiologists independently measured minimum, mean and maximum ADC, each using three ROI placement approaches:1 - small 2D-ROI, 2 - large 2D-ROI and 3 - 3D-ROI covering the whole lesion. One reader performed all measurements twice. Median ADC values, diagnostic performance, reproducibility, and measurement time were calculated and compared between all combinations of ROI placement approaches and ADC parameters.
resultsMedian ADC values differed significantly between the ROI placement approaches (p < .001). Minimum ADC showed the best diagnostic performance (AUC .928-.956), followed by mean ADC obtained from 2D ROIs (.926-.94). Minimum and mean ADC showed high intra- (ICC .85-.94) and inter-reader reproducibility (ICC .74-.94). Median measurement time was significantly shorter for the 2D ROIs (p < .001).
conclusionsROI placement significantly influences ADC values measured in breast tumours. Minimum and mean ADC acquired from 2D-ROIs are useful for the differentiation of benign and malignant breast lesions, and are highly reproducible, with rapid measurement. KEY POINTS: • Region of interest placement significantly influences apparent diffusion coefficient of breast tumours. • Minimum and mean apparent diffusion coefficient perform best and are reproducible. • 2D regions of interest perform best and provide rapid measurement times.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.