ArticleScientific reports2016
Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- Differences in Physiological Performance and Gut Microbiota between Deep-Sea and Coastal Aquaculture of Thachinotus Ovatus: A Metagenomic Approach.Animals : an open access journal from MDPI · 2023Article
- Exploring the role of gut microbiota in advancing personalized medicine.Frontiers in microbiology · 2023Review
- Bacterial polysaccharides-A big source for prebiotics and therapeutics.Frontiers in nutrition · 2022Review
- Bacterial Enoyl-Reductases: The Ever-Growing List of Fabs, Their Mechanisms and Inhibition.Frontiers in microbiology · 2022Review
- Early genetic diagnosis of clarithromycin resistance inWorld journal of gastroenterology · 2021Article
- Experimental evolution in morbidostat reveals converging genomic trajectories on the path to triclosan resistance.Microbial genomics · 2021Article
- Triclosan Tolerance Is Driven by a Conserved Mechanism in DiverseApplied and environmental microbiology · 2021Article
- Toothbrush microbiomes feature a meeting ground for human oral and environmental microbiota.Microbiome · 2021Article
- Nonactive-Site Mutations inACS omega · 2020Article
- Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro.PloS one · 2020Article
- Triclosan-Selected Host-Associated Microbiota Perform Xenobiotic Biotransformations in Larval Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Biochemical and Structural Insights Concerning Triclosan Resistance in a Novel YXScientific reports · 2019Article
- Article
- Biochemical and Structural Basis of Triclosan Resistance in a Novel Enoyl-Acyl Carrier Protein Reductase.Antimicrobial agents and chemotherapy · 2018Article
- Distribution of triclosan-resistant genes in major pathogenic microorganisms revealed by metagenome and genome-wide analysis.PloS one · 2018Article
- Household triclosan and triclocarban effects on the infant and maternal microbiome.EMBO molecular medicine · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triclosan (TCS) is a widely used antimicrobial agent and TCS resistance is considered to have evolved in diverse organisms with extensive use of TCS, but distribution of TCS resistance has not been well characterized. Functional screening of the soil metagenome in this study has revealed that a variety of target enoyl acyl carrier protein reductases (ENR) homologues are responsible for the majority of TCS resistance. Diverse ENRs similar to 7-α-hydroxysteroid dehydrogenase (7-α-HSDH), FabG, or the unusual YX7K-type ENR conferred extreme tolerance to TCS. The TCS-refractory 7-α HSDH-like ENR and the TCS-resistant YX7K-type ENR seem to be prevalent in human pathogenic bacteria, suggesting that a selective enrichment occurred in pathogenic bacteria in soil. Additionally, resistance to multiple antibiotics was found to be mediated by antibiotic resistance genes that co-localize with TCS resistance determinants. Further comparative analysis of ENRs from 13 different environments has revealed a huge diversity of both prototypic and metagenomic TCS-resistant ENRs, in addition to a selective enrichment of TCS-resistant specific ENRs in presumably TCS-contaminated environments with reduced ENR diversity. Our results suggest that long-term extensive use of TCS can lead to the selective emergence of TCS-resistant bacterial pathogens, possibly with additional resistance to multiple antibiotics, in natural environments.
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