Evidence map›Paper›PMID 27577858›Full record

ArticleScientific reports2016

Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica.

Wang Xiaojun, Liu Yan, Xu Hong, Zhang Xianghong, Li Shifeng, Xu Dingjie, Gao Xuemin, Zhang Lijuan, Zhang Bonan, Wei Zhongqiu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis.International journal of molecular sciences · 2022
    Review
  8. The integrated stress response in pulmonary disease.European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Wang XiaojunBasic Medical Collage, Hebei Medical University, Shijiazhuang, China.
Liu YanBasic Medical Collage, Hebei Medical University, Shijiazhuang, China.
Xu HongMedical Research Center, North China University of Science and Technology, Tangshan, China.
Zhang XianghongBasic Medical Collage, Hebei Medical University, Shijiazhuang, China.
Li ShifengMedical Research Center, North China University of Science and Technology, Tangshan, China.
Xu DingjieTraditional Chinese Medicine Collage, North China University of Science and Technology, Tangshan, China.
Gao XueminMedical Research Center, North China University of Science and Technology, Tangshan, China.
Zhang LijuanMedical Research Center, North China University of Science and Technology, Tangshan, China.
Zhang BonanMedical Research Center, North China University of Science and Technology, Tangshan, China.
Wei ZhongqiuMedical Research Center, North China University of Science and Technology, Tangshan, China.
Wang RuiminMedical Research Center, North China University of Science and Technology, Tangshan, China.
Darrell BrannDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yang FangBasic Medical Collage, Hebei Medical University, Shijiazhuang, China.
North China University of Science and Technology · CNHebei Medical University · CNAugusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silicosis is the most serious occupational disease in China. The objective of this study was to screen various proteins related to mechanisms of the pathogenesis of silicosis underlying the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis. We also aimed to explore a potential mechanism of acetylated α-tubulin (α-Ac-Tub) regulation by Ac-SDKP. Two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) were used to assess the different protein expression profiles between control and silicosis rats treated with or without Ac-SDKP. Twenty-nine proteins were identified to be potentially involved in the progression of silicosis and the anti-fibrotic effect of Ac-SDKP. Our current study finds that 1) the lost expression of Ac-Tub-α may be a new mechanism in rat silicosis; 2) treatment of silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast differentiation and collagen deposition accompanied by stabilizing the expression of α-Ac-Tub in vivo and in vitro, which is related with deacetylase family member 6 (HDAC6) and α-tubulin acetyl transferase (α-TAT1). Our data suggest that α-Ac-Tub regulation by Ac-SDKP may potentially be a new anti-fibrosis mechanism.

Indexed as

Protein Processing, Post-TranslationalAcetylationAcetyltransferasesActinsAmino Acid SequenceAngiotensin IIAnimalsCells, CulturedFibroblastsGene OntologyHistone Deacetylase 6LungMaleProtective FactorsProtein StabilityPulmonary FibrosisAcetyltransferasesActa2 protein, ratActinsAngiotensin IIHDAC6 protein, ratHistone Deacetylase 6Silicon DioxideTubulin

Identifiers

PMID27577858
PMCPMC5006047
OpenAlexW2513651835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.