Evidence map›Paper›PMID 27577602›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits.

Luke E Sebel, Steven M Graves, C Savio Chan, D James Surmeier

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  16. Classics in Chemical Neuroscience: Aripiprazole.ACS chemical neuroscience · 2017
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luke E SebelDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Steven M GravesDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
C Savio ChanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Northwestern University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Striatal Cell-specific Analysis of the Molecular Mechanisms of Antipsychotic DrugP50MH090963 · NIMH · ROCKEFELLER UNIVERSITY · PI FLAJOLET, MARC · 2010 to 2014
$9.8M
DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUMR37NS034696 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DALTON JAMES SURMEIER · 2001 to 2026
$7.3M
Dopaminergic and Muscarinic Signaling in the StriatumR01NS034696 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SURMEIER, DALTON JAMES · 1996 to 2018
$4.3M
Physiology Core - Interdepartmental Two-photon Imaging CenterP30NS054850 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2007 to 2012
$3.3M
L-DOPA-induced dyskinesias and dysregulation of striatopallidal neuronsF32NS084735 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRAVES, STEVEN MICHAEL · 2013 to 2014
$76k
NIGMS NIH HHS T32 GM008152NIMH NIH HHS P50 MH090963NINDS NIH HHS F32 NS084735NINDS NIH HHS P30 NS054850NINDS NIH HHS R01 NS034696NINDS NIH HHS R37 NS034696
6 · The paper itself

Abstract

Typical antipsychotic drugs are widely thought to alleviate the positive symptoms of schizophrenia by antagonizing dopamine D

Indexed as

AnimalsAntipsychotic AgentsCerebral CortexCorpus StriatumFemaleHaloperidolMaleMiceMice, TransgenicPerphenazineSignal TransductionAntipsychotic AgentsHaloperidolPerphenazine

Identifiers

PMID27577602
PMCPMC5312058
OpenAlexW2513891733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.