ArticleTrials2016
A Bayesian comparative effectiveness trial in action: developing a platform for multisite study adaptive randomization.
Article in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02260388 (Patient Assisted Intervention for Neuropathy), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial.JAMA neurology · 2021Trial
- A case study in teaching and learning the design, conduction, and analysis of Bayesian adaptive trials through an application.Journal of clinical and translational science · 2026Article
- A REDCap advanced randomization module to meet the needs of modern trials.Journal of biomedical informatics · 2025Article
- Use of EpicClinical trials (London, England) · 2025Article
- An Update on Recent Clinical Trial Data in Bloodstream Infection.Antibiotics (Basel, Switzerland) · 2024Review
- REDCap as an accreditation tool for academic programs in clinical research: A case study.Journal of clinical and translational science · 2024Article
- Conducting a bayesian multi-armed trial with response adaptive randomization for comparative effectiveness of medications for CSPN.Contemporary clinical trials communications · 2023Article
- The value of a two-armed Bayesian response adaptive randomization trial.Journal of biopharmaceutical statistics · 2023Article
- Comparative Effectiveness Research using Bayesian Adaptive Designs for Rare Diseases: Response Adaptive Randomization Reusing Participants.Statistics in biopharmaceutical research · 2023Article
- Using a Bayesian model of the joint distribution of pain and time on medication to decide on pain medication for neuropathy.Communications in statistics. Case studies, data analysis and applications · 2023Article
- Developing and testing a Corona VaccinE tRiAL pLatform (COVERALL) to study Covid-19 vaccine response in immunocompromised patients.BMC infectious diseases · 2022Article
- The Successful Synchronized Orchestration of an Investigator-Initiated Multicenter Trial Using a Clinical Trial Management System and Team Approach: Design and Utility Study.JMIR formative research · 2021Article
- The Bayesian Design of Adaptive Clinical Trials.International journal of environmental research and public health · 2021Review
- Bayesian accrual modeling and prediction in multicenter clinical trials with varying center activation times.Pharmaceutical statistics · 2020Article
- Article
- Point-of-Care Clinical Trials in Sports Medicine Research: Identifying Effective Treatment Interventions Through Comparative Effectiveness Research.Journal of athletic training · 2020Article
- Using Adaptive Designs to Avoid Selecting the Wrong Arms in Multiarm Comparative Effectiveness Trials.Statistics in biopharmaceutical research · 2019Article
- Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design.JAMIA open · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn the last few decades, the number of trials using Bayesian methods has grown rapidly. Publications prior to 1990 included only three clinical trials that used Bayesian methods, but that number quickly jumped to 19 in the 1990s and to 99 from 2000 to 2012. While this literature provides many examples of Bayesian Adaptive Designs (BAD), none of the papers that are available walks the reader through the detailed process of conducting a BAD. This paper fills that gap by describing the BAD process used for one comparative effectiveness trial (Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations) that can be generalized for use by others. A BAD was chosen with efficiency in mind. Response-adaptive randomization allows the potential for substantially smaller sample sizes, and can provide faster conclusions about which treatment or treatments are most effective. An Internet-based electronic data capture tool, which features a randomization module, facilitated data capture across study sites and an in-house computation software program was developed to implement the response-adaptive randomization.
resultsA process for adapting randomization with minimal interruption to study sites was developed. A new randomization table can be generated quickly and can be seamlessly integrated in the data capture tool with minimal interruption to study sites.
conclusionThis manuscript is the first to detail the technical process used to evaluate a multisite comparative effectiveness trial using adaptive randomization. An important opportunity for the application of Bayesian trials is in comparative effectiveness trials. The specific case study presented in this paper can be used as a model for conducting future clinical trials using a combination of statistical software and a web-based application.
trial registrationClinicalTrials.gov Identifier: NCT02260388 , registered on 6 October 2014.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.