ArticleBMC complementary and alternative medicine2016
Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Acrylamide-Induced Developmental and Molecular Toxicity in Drosophila melanogaster: The Role of Vanillic Acid in CncC/Keap1 Modulation.Journal of biochemical and molecular toxicology · 2026Article
- The potential therapeutic effect of quercetin on mitochondrial dysfunction in hepatorenal toxicity induced by aluminum chloride in an experimental rat model.Scientific reports · 2026Article
- Protective effect of thymoquinone against acrylamide-induced hepatotoxicity in the rat: role of MAPK and apoptosis pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities.Biomolecules · 2025Review
- Potential of dehydroepiandrosterone and quercetin to ameliorate copper oxide nanoparticles induced hepatotoxicity in albino wistar rats.Journal of molecular histology · 2024Article
- Estimation of genomic and mitochondrial DNA integrity in the renal tissue of mice administered with acrylamide and titanium dioxide nanoparticles.Scientific reports · 2023Article
- The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures.International journal of molecular sciences · 2023Review
- Unlocking the hepatoprotective potential of the parasitic plantFrontiers in pharmacology · 2023Article
- Estimation of genotoxicity, apoptosis and oxidative stress induction by TiOScientific reports · 2022Article
- Assessment of the genotoxicity of acrylamide.EFSA journal. European Food Safety Authority · 2022Article
- Article
- Biochemical evaluation and medicinal ability ofAmerican journal of translational research · 2022Article
- Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Protective Role of Quercetin in Carbon Tetrachloride Induced Toxicity in Rat Brain: Biochemical, Spectrophotometric Assays and Computational Approach.Molecules (Basel, Switzerland) · 2021Article
- Effects of Quercetin on Acrylamide-Induced Variation of Serum Elements in Rats.Biological trace element research · 2021Article
- Acrylamide-induced peripheral neuropathy: manifestations, mechanisms, and potential treatment modalities.Environmental science and pollution research international · 2021Review
- Article
- Amelioration of oxidative stress-mediated apoptosis in copper oxide nanoparticles-induced liver injury in rats by potent antioxidants.Scientific reports · 2020Article
- Quercetin and its role in biological functions: an updated review.EXCLI journal · 2018Article
- Amelioration of thioacetamide-induced liver toxicity in Wistar rats by rutin.International journal of immunopathology and pharmacology · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuercetin (QR), is a polyphenolic flavonoid compound which is found in large amounts in certain foods, and protects against oxidative stress. The current study was conducted to determine whether Quercetin can possibly exert hepatoprotective and antioxidant activity against acrylamide (ACR) induced toxicity in rats.
methodsFour groups of Wistar rats consisting of six rats each: (i) control group; (ii) ACR treated group (50 mg/kg bw); (iii) QR group: rats were treated with QR (10 mg/kg bw); (iv) QR (10 mg/kg bw) was given i.p. for 5 days followed by ACR (50 mg/kg bw) on 5th day (single dose).
resultsACR caused an elevation in 8-OH guanosine level and a reduction in Glutahione S-transferase (GST) activity. Administration of QR significantly protected liver tissue against hepatotoxic effect of acrylamide from amelioration of the marker enzyme (p < 0.05) and DNA damage (p < 0.01) as evident by comet assay and, besides some indices of histopathological alterations.
conclusionIt is concluded that QR could protect the liver against DNA damage induced by ACR probably is thus capable of ameliorating ACR-induced changes in the rat livers.
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