ArticleAMB Express2016
Degeneration of aflatoxin gene clusters in Aspergillus flavus from Africa and North America.
Article in AMB Express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 92 citations in OpenAlex.
- Distinction BetweenJournal of fungi (Basel, Switzerland) · 2025Article
- Exploring the Characteristics of AtoxigenicJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- Structure of Aspergillus flavus populations associated with maize in Greece, Spain, and Serbia: Implications for aflatoxin biocontrol on a regional scale.Environmental microbiology reports · 2024Article
- Telomere-to-telomere genome assembly of the aflatoxin biocontrol agentMicrobiology resource announcements · 2024Article
- Keeping toxigenicFrontiers in microbiology · 2024Article
- Aspergillus population diversity and its role in aflatoxin contamination of cashew nuts from coastal Kenya.PloS one · 2024Article
- Mitigation of aflatoxin contamination of maize, groundnut, and sorghum by commercial biocontrol products in farmers' fields across Burkina Faso, Mali, Niger, and Togo.CABI agriculture and bioscience · 2024Article
- Impact of storage conditions on the shelf life of aflatoxin biocontrol products containing atoxigenic isolates ofCABI agriculture and bioscience · 2024Article
- Detection of Aflatoxin B1-producingCurrent medical mycology · 2023Article
- Complete genome of the toxic mold Aspergillus pseudotamarii isolate NRRL 25517 reveals genomic instability of the aflatoxin biosynthesis cluster.G3 (Bethesda, Md.) · 2023Article
- Non-AflatoxigenicACS omega · 2023Article
- Article
- Aflatoxin contamination of maize and groundnut in Burundi: Distribution of contamination, identification of causal agents and potential biocontrol genotypes ofFrontiers in microbiology · 2023Article
- Molecular Characterization ofPolish journal of microbiology · 2022Article
- Article
- Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change.Frontiers in microbiology · 2022Review
- Impact of frequency of application on the long-term efficacy of the biocontrol product Aflasafe in reducing aflatoxin contamination in maize.Frontiers in microbiology · 2022Article
- Asymmetrical lineage introgression and recombination in populations of Aspergillus flavus: Implications for biological control.PloS one · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus flavus is the most common causal agent of aflatoxin contamination of food and feed. However, aflatoxin-producing potential varies widely among A. flavus genotypes with many producing no aflatoxins. Some non-aflatoxigenic genotypes are used as biocontrol agents to prevent contamination. Aflatoxin biosynthesis genes are tightly clustered in a highly conserved order. Gene deletions and presence of single nucleotide polymorphisms (SNPs) in aflatoxin biosynthesis genes are often associated with A. flavus inability to produce aflatoxins. In order to identify mechanisms of non-aflatoxigenicity in non-aflatoxigenic genotypes of value in aflatoxin biocontrol, complete cluster sequences of 35 A. flavus genotypes from Africa and North America were analyzed. Inability of some genotypes to produce aflatoxin resulted from deletion of biosynthesis genes. In other genotypes, non-aflatoxigenicity originated from SNP formation. The process of degeneration differed across the gene cluster; genes involved in early biosynthesis stages were more likely to be deleted while genes involved in later stages displayed high frequencies of SNPs. Comparative analyses of aflatoxin gene clusters provides insight into the diversity of mechanisms of non-aflatoxigenicity in A. flavus genotypes used as biological control agents. The sequences provide resources for both diagnosis of non-aflatoxigenicity and monitoring of biocontrol genotypes during biopesticide manufacture and in the environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.