ArticleMuscle & nerve2017
Endurance neuromuscular electrical stimulation training improves skeletal muscle oxidative capacity in individuals with motor-complete spinal cord injury.
Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07771010 (The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus
Open the trial in the graphWho cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The effects of exercise training on cardiometabolic health in adults with spinal cord injury: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- The additive effect of neuromuscular electrical stimulation and resistance training on muscle mass and strength.European journal of applied physiology · 2025Pooled it
- Effects of neuromuscular electrical stimulation on glycemic control: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Skeletal muscle hypertrophy and enhanced mitochondrial bioenergetics following electrical stimulation exercises in spinal cord injury: a randomized clinical trial.European journal of applied physiology · 2025Trial
- Cardiorespiratory Fitness Improvements Following Low-Frequency Training Are Not Inferior to High-Frequency Training Matched for Intensity and Volume.Scandinavian journal of medicine & science in sports · 2025Trial
- The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Signaling for Glucose Utilization, Myofiber Distribution, and Metabolic Function after Spinal Cord Injury.International journal of environmental research and public health · 2023Trial
- Strategies to mitigate muscle mass loss in individuals with spinal cord injury.The journal of spinal cord medicine · 2026Review
- Preserved muscle oxidative capacity in COPD patients with hypoxemia treated by long term OEuropean journal of applied physiology · 2026Article
- Muscle oxygenation regulation in physical therapy and rehabilitation.Medical gas research · 2026Review
- The Acute Physiological Effects of Multiple Muscle Stimulation.Muscles (Basel, Switzerland) · 2026Article
- Impact of Combined Neuromuscular Electrical Stimulation (Comb-NMES) on Glucose Signaling and Muscle Myofiber Distribution in a Patient with Acute Spinal Cord Injury and Lower Motor Neuron Lesion.Journal of clinical medicine · 2025Article
- Muscle Endurance Training in a Person with Friedreich's Ataxia.Muscles (Basel, Switzerland) · 2025Article
- Global trends in scientific production on physical exercise and spinal cord injury.Frontiers in sports and active living · 2025Review
- Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use.The journal of spinal cord medicine · 2024Article
- The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Cross-Sectional Area and Inflammatory Signaling.International journal of molecular sciences · 2024Article
- Multidisciplinary approach on divergent outcomes in spinal muscular atrophies: comparing DYNC1H1 and SMN1 gene mutations.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Effect of Neuromuscular Electrical Stimulation Training on Control of Involuntary Muscular Torque and Stimulation Intensity in Older Adults.International journal of exercise science · 2023Article
- Article
- Safety and efficacy of electrical stimulation for lower-extremity muscle weakness in intensive care unit 2019 Novel Coronavirus patients: A phase I double-blinded randomized controlled trial.Frontiers in medicine · 2022Article
- Effects of arm cranking exercise on muscle oxygenation between active and inactive muscles in people with spinal cord injury.The journal of spinal cord medicine · 2021Observational
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
introductionSpinal cord injury (SCI) results in skeletal muscle atrophy, increases in intramuscular fat, and reductions in skeletal muscle oxidative capacity. Endurance training elicited with neuromuscular electrical stimulation (NMES) may reverse these changes and lead to improvement in muscle metabolic health.
methodsFourteen participants with complete SCI performed 16 weeks of home-based endurance NMES training of knee extensor muscles. Skeletal muscle oxidative capacity, muscle composition, and blood metabolic and lipid profiles were assessed pre- and post-training.
resultsThere was an increase in number of contractions performed throughout the duration of training. The average improvement in skeletal muscle oxidative capacity was 119%, ranging from -14% to 387% (P = 0.019). There were no changes in muscle composition or blood metabolic and lipid profiles.
conclusionEndurance training improved skeletal muscle oxidative capacity, but endurance NMES of knee extensor muscles did not change blood metabolic and lipid profiles. Muscle Nerve 55: 669-675, 2017.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.